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Literature summary for 2.7.6.3 extracted from
- Chemical transformation is not rate-limiting in the reaction catalyzed by Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (2002), Biochemistry, 41, 8777-8783.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | because the enzyme is essential for microorganisms but is absent from human and animals, the enzyme is an excellent target for developing antimicrobial agent | Escherichia coli |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for binding of nucleotides and for the binding of 6-hydroxymethyl-7,8-dihydropteridine | Escherichia coli |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 6-hydroxymethyl-7,8-dihydropteridine | - |
Escherichia coli | AMP + 6-hydroxymethyl-7,8-dihydropteridine diphosphate | - |
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Release 2023.1 (January 2023)
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