Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | the enzyme localizes in photoreceptor and central brain synapses | Drosophila melanogaster | - |
Synonyms | Comment | Organism |
---|---|---|
nicotinamide mononucleotide adenylyltransferase | - |
Drosophila melanogaster |
NMNAT | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme loss results in ubiquitination, mislocalization and aggregation of the Bruchpilot protein, and subsequent active zone degeneration | Drosophila melanogaster |
physiological function | the enzyme is required for maintaining active zone structural integrity in Drosophila by interacting with the active zone protein Bruchpilot and shielding it from activity-induced ubiquitin-proteasome-mediated degradation. The enzyme specifically maintains active zone structure by direct protein-protein interaction | Drosophila melanogaster |