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Literature summary for 2.7.7.1 extracted from
- Structure of nicotinamide mononucleotide adenylyltransferase: a key enzyme in NAD(+) biosynthesis (2000), Structure, 8, 993-1004.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | given its vital role in cell life, the enzyme represents a possible target for the development of new antibacterial agents | Methanocaldococcus jannaschii |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystals of the enzyme in complex with ATP are grown using the hanging-drop vapor-diffusion method. The structure in complex with ATP has been solved by X-ray crystallography at 2.0 A resolution, using a combination of single isomorphous replacement and density modification techniques. The structure reveals a hexamer with 32 point group symmetry composed of alpha/beta topology subunits | Methanocaldococcus jannaschii |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + nicotinamide ribonucleotide | Methanocaldococcus jannaschii | the enzyme plays a key role in NAD+ biosynthesis | diphosphate + NAD+ | - |
? |  |
| ATP + nicotinamide ribonucleotide | Methanocaldococcus jannaschii DSM 2661 | the enzyme plays a key role in NAD+ biosynthesis | diphosphate + NAD+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methanocaldococcus jannaschii | Q57961 | - |
- |
| Methanocaldococcus jannaschii DSM 2661 | Q57961 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + nicotinamide ribonucleotide | the enzyme plays a key role in NAD+ biosynthesis | Methanocaldococcus jannaschii | diphosphate + NAD+ | - |
? | |
| ATP + nicotinamide ribonucleotide | the enzyme plays a key role in NAD+ biosynthesis | Methanocaldococcus jannaschii DSM 2661 | diphosphate + NAD+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | - |
Methanocaldococcus jannaschii |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NMN AT | - |
Methanocaldococcus jannaschii |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays a key role in NAD+ biosynthesis | Methanocaldococcus jannaschii |
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