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Literature summary for 2.7.7.13 extracted from

  • Watt, G.M.; Flitsch, S.L.; Fey, S.; Elling, L.; Kragl, U.
    The preparation of deoxy derivatives of mannose-1-phosphate and their substrate specificity towards recombinant GDP-mannose pyrophosphorylase from Salmonella enterica, group B (2000), Tetrahedron, 11, 621-628.
No PubMed abstract available
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Application

Application Comment Organism
synthesis enzyme can be used for the synthesis of GDPmannose deoxy derivatives Salmonella enterica

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.014
-
 alpha-D-mannose 1-phosphate pH 8.0, 25°C, recombinant enzyme Salmonella enterica
0.94
-
 4-deoxy-alpha-D-lyxo-hexose 1-phosphate pH 8.0, 25°C, recombinant enzyme Salmonella enterica
13.8
-
 alpha-D-lyxose-1-phosphate pH 8.0, 25°C, recombinant enzyme Salmonella enterica
15.2
-
 3-deoxy-D-arabino-hexose 1-phosphate pH 8.0, 25°C, recombinant enzyme Salmonella enterica
41.1
-
 2-deoxy-D-glucose 1-phosphate pH 8.0, 25°C, recombinant enzyme Salmonella enterica

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + 2-deoxy-alpha-D-glucose-1-phosphate recombinant GDPmannose pyrophosphorylase, 15% of activity with mannose 1-phosphate Salmonella enterica GDP-2-deoxy-alpha-D-glucose + diphosphate
-
 ?
GTP + 3-deoxy-alpha-D-arabino-hexose-1-phosphate recombinant GDPmannose pyrophosphorylase, 70% of activity with mannose 1-phosphate Salmonella enterica GDP-3-deoxy-alpha-D-arabino-hexose + diphosphate
-
 ?
GTP + 4-deoxy-alpha-D-lyxo-hexose 1-phosphate
-
 Salmonella enterica GDP-4-deoxy-alpha-D-lyxo-hexose + diphosphate
-
 ?
GTP + 4-deoxy-alpha-D-lyxo-hexose-1-phosphate recombinant GDPmannose pyrophosphorylase, 22% of activity with mannose 1-phosphate Salmonella enterica GDP-4-deoxy-alpha-D-lyxo-hexose + diphosphate
-
 ?
GTP + alpha-D-lyxose-1-phosphate recombinant GDPmannose pyrophosphorylase, 12% of activity with mannose 1-phosphate Salmonella enterica GDPalpha-D-lyxose + diphosphate
-
 ?
GTP + alpha-D-lyxose-1-phosphate
-
 Salmonella enterica GDP-alpha-D-lyxose + diphosphate
-
 ?
GTP + alpha-D-mannose 1-phosphate
-
 Salmonella enterica diphosphate + GDP-mannose
-
 ?