Literature summary for 2.7.7.14 extracted from

Zhu, L.; Bakovic, M.
Breast cancer cells adapt to metabolic stress by increasing ethanolamine phospholipid synthesis and CTP:ethanolaminephosphate cytidylyltransferase-Pcyt2 activity (2012), Biochem. Cell Biol., 90, 188-199.

Search for more literature for 2.7.7.14

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	two splice variants, Pcyt2alpha and Pcyt2beta	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
CTP:ethanolaminephosphate cytidylyltransferase	-	Homo sapiens
Pcyt2	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	serum-deficient MCF-7 cells adapt to stress conditions by increasing synthesis and content of phosphatidylethanolamine and diacylglycerol. The biosynthesis of phosphatidylethanolamine from diacylglycerol and ethanolamine is regulated at the level of formation of CDP-ethanolamine, the metabolic step catalyzed by Pcyt2. The catalytic activity of Pcyt2 is elevated 2-3fold, yet the enzyme remains rate-limiting in serum-deficient cells. The mRNA levels of two splice variants, Pcyt2alpha and Pcyt2beta, are 1.5-3fold higher in deficient cells. Elevated diacylglycerol formation and the increased activity of the rate-regulatory enzyme Pcyt2 are critical modulators of the phosphatidylethanolamine Kennedy pathway, and total phosphatidylethanolamine content in serum-deprived breast cancer cells	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)