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Literature summary for 2.7.7.15 extracted from

  • Ridsdale, R.; Tseu, I.; Roth-Kleiner, M.; Wang, J.; Post, M.
    Increased phosphatidylcholine production but disrupted glycogen metabolism in fetal type II cells of mice that overexpress CTP:phosphocholine cytidylyltransferase (2004), J. Biol. Chem., 279, 55946-55957.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Lipids regulation of activity by reversible association with membrane lipids Mus musculus
Lipids regulation of activity by reversible association with membrane lipids Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
full length enzyme and various truncated enzymes expressed in transgenic mice Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane enzyme is activated when bound to vesicles Mus musculus 16020
-
membrane enzyme is activated when bound to vesicles Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + choline phosphate Mus musculus rate limiting enzyme for the synthesis of phosphatidylcholine diphosphate + CDP-choline
-
?
CTP + choline phosphate Rattus norvegicus rate limiting enzyme for the synthesis of phosphatidylcholine diphosphate + CDP-choline
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein 16 serine and 2 tyrosine residues available for phosphorylation, phosphorylation is associated with decreased membrane binding and therefore, decreased activity Mus musculus
phosphoprotein 16 serine and 2 tyrosine residues available for phosphorylation, phosphorylation is associated with decreased membrane binding and therefore, decreased activity Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
Mus musculus
-
lung
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + choline phosphate
-
Mus musculus diphosphate + CDP-choline
-
?
CTP + choline phosphate
-
Rattus norvegicus diphosphate + CDP-choline
-
?
CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine Mus musculus diphosphate + CDP-choline
-
?
CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine Rattus norvegicus diphosphate + CDP-choline
-
?

Synonyms

Synonyms Comment Organism
More four isoforms, CCTalpha ubiquitously expressed, whereas CCTbeta 1,-2, and -3 restricted in distribution Mus musculus
More four isoforms, CCTalpha ubiquitously expressed, whereas CCTbeta 1,-2, and -3 restricted in distribution Rattus norvegicus