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Literature summary for 2.7.7.15 extracted from

  • Strakova, J.; Demizieux, L.; Campenot, R.B.; Vance, D.E.; Vance, J.E.
    Involvement of cin axonal phosphatidylcholine synthesis and branching of neurons (2011), Biochim. Biophys. Acta, 1811, 617-625.
    View publication on PubMed
Search for more literature for 2.7.7.15

Organism

Organism UniProt Comment Textmining
Mus musculus
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 two isozymes CTalpha and CTbeta2
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Rattus norvegicus
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 two isozymes CTalpha and CTbeta2
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Rattus norvegicus Sprague-Dawley
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 two isozymes CTalpha and CTbeta2
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Mus musculus
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astrocyte
-
 Rattus norvegicus
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brain
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 Mus musculus
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brain
-
 Rattus norvegicus
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ganglion superior cervical ganglia Mus musculus
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ganglion superior cervical ganglia Rattus norvegicus
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neuron Cortical, primary sympathetic and cultured primary, isozyme CTbeta2 mRNA and protein are abundant in distal axons of mouse sympathetic neurons, whereas isozyme CTalpha mRNA and protein are not detected Mus musculus
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neuron primary sympathetic and cultured primary, isozyme CTbeta2 mRNA and protein are abundant in distal axons of mouse sympathetic neurons, whereas isozyme CTalpha mRNA and protein are not detected Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
CTP:phosphocholine cytidylyltransferase-beta2
-
 Mus musculus
CTP:phosphocholine cytidylyltransferase-beta2
-
 Rattus norvegicus

Expression

Organism Comment Expression
Mus musculus in cultured primary neurons nerve growth factor increases the amount of isozyme CTbeta2, but not CTalpha, mRNA and protein up
Rattus norvegicus in cultured primary neurons nerve growth factor increases the amount of isozyme CTbeta2, but not CTalpha, mRNA and protein up

General Information

General Information Comment Organism
malfunction isozyme CTbeta2 deficiency in distal axons reduces the incorporation of choline into by 95% whereas phosphatidylcholine synthesis in cell bodies/proximal axons is unaltered. Brains of mice lacking CTbeta2 have normal phosphatidylethanolamine content despite having 35% lower enzyme activity than wild-type brains. Axon branching, but not axon extension, is impaired in CTbeta2-deficient neurons. Phenotypes, overview Mus musculus
malfunction isozyme CTbeta2 deficiency in distal axons reduces the incorporation of choline into by 95% whereas phosphatidylcholine synthesis in cell bodies/proximal axons is unaltered. Brains of mice lacking CTbeta2 have normal phosphatidylethanolamine content despite having 35% lower enzyme activity than wild-type brains. Axon branching, but not axon extension, is impaired in CTbeta2-deficient neurons. Phenotypes, overview Rattus norvegicus
physiological function importance of isozyme CTbeta2 for phosphatidylcholine synthesis as well as for axon formation, growth and branching of primary sympathetic neurons Mus musculus
physiological function importance of isozyme CTbeta2 for phosphatidylcholine synthesis as well as for axon formation, growth and branching of primary sympathetic neurons Rattus norvegicus