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Literature summary for 2.7.7.19 extracted from

  • Burns, D.M.; DAmbrogio, A.; Nottrott, S.; Richter, J.D.
    CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation (2011), Nature, 473, 105-108.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6PIY7
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-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast primary foreskin fibroblasts Homo sapiens
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Synonyms

Synonyms Comment Organism
germline development 2
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Homo sapiens
GLD2
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Homo sapiens
GLD4
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Homo sapiens

General Information

General Information Comment Organism
physiological function depletion of isoform Gld2 promotes rather than inhibits p53 mRNA polyadenylation/translation, induces premature senescence and enhances the stability of cytoplasmic polyadenylation element binding protein CPEB mRNA. TheCPEB 3' untranslated region contains two miR-122 binding sites, which when deleted, elevate mRNA translation. miR-122 is present in primary fibroblasts and destabilizes by Gld2 depletion Homo sapiens
physiological function isoform GLD4 regulates p53 polyadenylation/translation in a cytoplasmic polyadenylation element binding protein CPEB dependent manner Homo sapiens