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Literature summary for 2.7.7.3 extracted from

  • Martin, D.P.; Drueckhammer, D.G.
    Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase (1993), Biochem. Biophys. Res. Commun., 192, 1155-1161.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.19
-
pantetheine 4'-phosphate pH 8 Corynebacterium ammoniagenes
0.53
-
ATP pH 8 Corynebacterium ammoniagenes

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Corynebacterium ammoniagenes 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35400
-
alpha3, 3 * 35400, SDS-PAGE Corynebacterium ammoniagenes
108000
-
gel filtration Corynebacterium ammoniagenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pantetheine 4'-phosphate Corynebacterium ammoniagenes involved in coenzyme A biosynthesis diphosphate + 3'-dephospho-CoA
-
?

Organism

Organism UniProt Comment Textmining
Corynebacterium ammoniagenes
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Corynebacterium ammoniagenes

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
8.5
-
-
Corynebacterium ammoniagenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxy-ATP + pantetheine 4'-phosphate phosphorylation at 27% the rate of ATP Corynebacterium ammoniagenes ?
-
?
ATP + pantetheine 4'-phosphate no substrates are GTP, ITP, UTP, or CTP Corynebacterium ammoniagenes diphosphate + 3'-dephospho-CoA
-
?
ATP + pantetheine 4'-phosphate involved in coenzyme A biosynthesis Corynebacterium ammoniagenes diphosphate + 3'-dephospho-CoA
-
?

Subunits

Subunits Comment Organism
trimer alpha3, 3 * 35400, SDS-PAGE Corynebacterium ammoniagenes