Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-glutamine | establishes feed-back control by stimulating the adenylylation and inactivation of the [L-glutamate:ammonia ligase (ADP-forming)] | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxoglutarate | slight activation at 20 mM | Escherichia coli | |
3-phosphoglycerate | 66% inhibition at 20 mM | Escherichia coli | |
ATP | 74% inhibition at 20 mM | Escherichia coli | |
diphosphate | 28% inhibition at 2 mM | Escherichia coli | |
UTP | 48% inhibition at 10 mM | Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | stimulates | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [L-glutamate:ammonia ligase (ADP-forming)] | Escherichia coli | inactivation of [L-glutamate:ammonia ligase (ADP-forming)] by attachment of the adenylyl moiety of ATP | diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP) | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [L-glutamate:ammonia ligase (ADP-forming)] | - |
Escherichia coli | diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP) | - |
r | |
ATP + [L-glutamate:ammonia ligase (ADP-forming)] | inactivation of [L-glutamate:ammonia ligase (ADP-forming)] by attachment of the adenylyl moiety of ATP | Escherichia coli | diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP) | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | inhibitory at higher comcentrations | Escherichia coli |