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Literature summary for 2.7.7.42 extracted from

  • Rhee, S.G.; Park, R.; Wittenberger, M.
    New enzymic assays for glutamine synthetase adenylytransferase and its regulatory protein PIIA (1978), Anal. Biochem., 88, 174-185.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
L-glutamine required Salmonella enterica subsp. enterica serovar Typhimurium
L-glutamine required Escherichia coli
L-glutamine required Pseudomonas putida
PII regulatory protein PIIA is required Salmonella enterica subsp. enterica serovar Typhimurium
PII regulatory protein PIIA is required Escherichia coli
PII regulatory protein PIIA is required Pseudomonas putida
PII regulatory protein activity is modulated by a regulatory protein PII, which exists in two interconvertible forms, PIIA and PIID, the unmodified form PIIA stimulates the adenylylation of [L-glutamate:ammonia ligase (ADP-forming)] , the uridylated form PIID is required for deadenylylation Salmonella enterica subsp. enterica serovar Typhimurium
PII regulatory protein activity is modulated by a regulatory protein PII, which exists in two interconvertible forms, PIIA and PIID, the unmodified form PIIA stimulates the adenylylation of [L-glutamate:ammonia ligase (ADP-forming)] , the uridylated form PIID is required for deadenylylation Escherichia coli
PII regulatory protein activity is modulated by a regulatory protein PII, which exists in two interconvertible forms, PIIA and PIID, the unmodified form PIIA stimulates the adenylylation of [L-glutamate:ammonia ligase (ADP-forming)] , the uridylated form PIID is required for deadenylylation Pseudomonas putida

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Salmonella enterica subsp. enterica serovar Typhimurium
Mg2+ activates Escherichia coli
Mg2+ activates Pseudomonas putida
Mn2+ activates, in presence of PIIA Salmonella enterica subsp. enterica serovar Typhimurium
Mn2+ activates, in presence of PIIA Escherichia coli
Mn2+ activates, in presence of PIIA Pseudomonas putida

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [L-glutamate:ammonia ligase (ADP-forming)] Salmonella enterica subsp. enterica serovar Typhimurium
-
diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)
-
r
ATP + [L-glutamate:ammonia ligase (ADP-forming)] Escherichia coli
-
diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)
-
r
ATP + [L-glutamate:ammonia ligase (ADP-forming)] Pseudomonas putida
-
diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)
-
r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
W
-
Pseudomonas putida
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Salmonella enterica subsp. enterica serovar Typhimurium
partial Escherichia coli
partial Pseudomonas putida

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
assay method Salmonella enterica subsp. enterica serovar Typhimurium
additional information
-
assay method Escherichia coli
additional information
-
assay method Pseudomonas putida

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [L-glutamate:ammonia ligase (ADP-forming)]
-
Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)
-
r
ATP + [L-glutamate:ammonia ligase (ADP-forming)]
-
Escherichia coli diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)
-
r
ATP + [L-glutamate:ammonia ligase (ADP-forming)]
-
Pseudomonas putida diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)
-
r
ATP + [L-glutamate:ammonia ligase (ADP-forming)]
-
Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)
-
r
ATP + [L-glutamate:ammonia ligase (ADP-forming)]
-
Escherichia coli diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)
-
r
ATP + [L-glutamate:ammonia ligase (ADP-forming)]
-
Pseudomonas putida diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)
-
r

Synonyms

Synonyms Comment Organism
ATASE
-
Salmonella enterica subsp. enterica serovar Typhimurium
ATASE
-
Escherichia coli
ATASE
-
Pseudomonas putida

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
26
-
assay at Salmonella enterica subsp. enterica serovar Typhimurium
26
-
assay at Escherichia coli
26
-
assay at Pseudomonas putida
37
-
assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
about, assay at Salmonella enterica subsp. enterica serovar Typhimurium
7.5
-
about, assay at Escherichia coli
7.5
-
about, assay at Pseudomonas putida

Cofactor

Cofactor Comment Organism Structure
ATP
-
Salmonella enterica subsp. enterica serovar Typhimurium
ATP
-
Escherichia coli
ATP
-
Pseudomonas putida