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Literature summary for 2.7.7.43 extracted from

  • Munster, A.K.; Eckhardt, M.; Potvin, B.; Muhlenhoff, M.; Stanley, P.; Gerardy-Schahn, R.
    Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs (1998), Proc. Natl. Acad. Sci. USA, 95, 9140-9145.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.43

Cloned(Commentary)

Cloned (Comment) Organism
cloning is achieved by complementation of the Chineses hamster ovary lec32 mutation that causes a deficiency in CMP-N-acetylneuraminate synthetase activity, it also causes polysialic acid to be expressed in the capsule of the CMP-Neu5Ac synthetase negative Escherichia coli mutant EV5 Mus musculus
expression in CHO cells or Escherichia coli Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48058
-
 x * 48058, calculation from nucleotide sequence Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + N-acylneuraminate Mus musculus production of CMP-N-acetylneuraminate is required for the synthesis of sialylated glycoconjugates diphosphate + CMP-N-acylneuraminate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q99KK2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AtT-20 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + N-acylneuraminate
-
 Mus musculus diphosphate + CMP-N-acylneuraminate
-
 ?
CTP + N-acylneuraminate production of CMP-N-acetylneuraminate is required for the synthesis of sialylated glycoconjugates Mus musculus diphosphate + CMP-N-acylneuraminate
-
 ?

Subunits

Subunits Comment Organism
? x * 48058, calculation from nucleotide sequence Mus musculus