Literature summary for 2.7.7.43 extracted from

Mosimann, S.C.; Gilbert, M.; Dombroswki, D.; To, R.; Wakarchuk, W.; Strynadka, N.C.
Structure of a sialic acid-activating synthetase, CMP-acylneuraminate synthetase in the presence and absence of CDP (2001), J. Biol. Chem., 276, 8190-8196.

Search for more literature for 2.7.7.43

Application

Application	Comment	Organism
medicine	the enzyme is involved in the production of activated sialic acids. Sialic acids are virulence factors in a variety of bacterial species, e.g. Neisseria menigitidis. As such, the identification of the bacterial CMP-NeuAc synthetase active site can serve as a starting point for rational drug design strategies	Neisseria meningitidis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CTP + N-acylneuraminate	Neisseria meningitidis	the enzyme is involved in the production of activated sialic acids	diphosphate + CMP-N-acylneuraminate	-	?

Organism

Organism	UniProt	Comment	Textmining
Neisseria meningitidis	P0A0Z8	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Neisseria meningitidis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CTP + N-acylneuraminate	-	Neisseria meningitidis	diphosphate + CMP-N-acylneuraminate	-	?
CTP + N-acylneuraminate	the enzyme is involved in the production of activated sialic acids	Neisseria meningitidis	diphosphate + CMP-N-acylneuraminate	-	?

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Release 2023.1 (January 2023)