Cloned (Comment) | Organism |
---|---|
expressed in CHO cells, HeLa cells, and NIH-3T3 cells | Mus musculus |
expression in CHO cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
DELTA408-424 | deletion mutant devoid of the second putative nuclear export signal, by immunofluorescent microscopy it is shown that this deletion mutant has an increased nuclear localisation combined with a decreased cytoplasmic localisation | Mus musculus |
DELTA61-69 | deletion mutant devoid of the first putative nuclear export signal, by immunofluorescent microscopy it is shown that is deletion mutant has an increased nuclear localisation combined with a decreased cytoplasmic localisation | Mus musculus |
additional information | by deletion mutant analysis it is demonstrated that mouse CSS contains two nuclear export signals which regulate the transport of the protein from nucleus towards cytosol | Mus musculus |
additional information | the two nuclear export signals of mouse CSS are conserved among mammals and fish CSSs but they are not present in bacteria or insect CSS | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
cytoplasm | a small, but significant population of the mouse CMP-sialic acid synthetase is also present in cytoplasm | Mus musculus | 5737 | - |
nucleus | vertebrate CSS are usually localised in the nucleus due to a nuclear localisation signal, however in mouse a small proportion of CSS is also present in cytoplasm due to two nuclear export signals | Mus musculus | 5634 | - |
nucleus | mostly localized in nucleus | Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q99KK2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + N-acylneuraminate | - |
Mus musculus | diphosphate + CMP-N-acylneuraminate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CMP-sialic acid synthetase | - |
Mus musculus |
CSS | - |
Mus musculus |
mCSS | - |
Mus musculus |