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Literature summary for 2.7.7.48 extracted from

  • Salgado, P.S.; Makeyev, E.V.; Butcher, S.J.; Bamford, D.H.; Stuart, D.I.; Grimes, J.M.
    The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase (2004), Structure, 12, 307-316.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
cocrystallization of RNA oligonucleotides with the polymerase Cystovirus phi6

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
Cystovirus phi6

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activation of the RNA/polymerase complex by the addition of substrate and Mg2+ initiates a single round of reaction within the crystal to form a dead-end complex that partially collapses within the enzyme active site Cystovirus phi6

Organism

Organism UniProt Comment Textmining
Cystovirus phi6 P11124
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
Cystovirus phi6 diphosphate + RNAn+1
-
?

Synonyms

Synonyms Comment Organism
RNA-dependent RNA polymerase
-
Cystovirus phi6