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Literature summary for 2.7.7.48 extracted from

  • Gopalsamy, A.; Shi, M.; Ciszewski, G.; Park, K.; Ellingboe, J.W.; Orlowski, M.; Feld, B.; Howe, A.Y.
    Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase (2006), Bioorg. Med. Chem. Lett., 16, 2532-2534.
    View publication on PubMed
Search for more literature for 2.7.7.48

Inhibitors

Inhibitors Comment Organism Structure
(5,7-difluoro-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
-
 Hepacivirus C
(5,8-dicyano-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
-
 Hepacivirus C
(5-cyano-8-fluoro-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
-
 Hepacivirus C
(5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
-
 Hepacivirus C
(5-cyano-8-methyl-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
-
 Hepacivirus C
3-allyl-5,8-dichloro-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
-
 Hepacivirus C
3-allyl-8-cyano-5-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
-
 Hepacivirus C
3-allyl-8-cyano-5-methyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
-
 Hepacivirus C
3-allyl-8-cyano-7-fluoro-5-methyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
-
 Hepacivirus C
3-butyl-5,8-dichloro-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
-
 Hepacivirus C
3-butyl-8-cyano-5-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
-
 Hepacivirus C
3-butyl-8-cyano-5-methyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
-
 Hepacivirus C
3-butyl-8-cyano-7-fluoro-5-methyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
-
 Hepacivirus C
5,8-dichloro-1-propyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid
-
 Hepacivirus C
5,8-dichloro-3-propyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
-
 Hepacivirus C
5-cyano-8-fluoro-1-propyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid
-
 Hepacivirus C
5-cyano-8-methyl-1-propyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid
-
 Hepacivirus C
8-chloro-1-propyl-5-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid
-
 Hepacivirus C
8-cyano-5-fluoro-3-propyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
-
 Hepacivirus C
8-cyano-5-methyl-3-propyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
-
 Hepacivirus C
8-cyano-7-fluoro-5-methyl-3-propyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
-
 Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Synonyms

Synonyms Comment Organism
NS5B enzyme
-
 Hepacivirus C

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00055
-
-
 Hepacivirus C 5,8-dichloro-3-propyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
0.00057
-
-
 Hepacivirus C (5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
0.0012
-
-
 Hepacivirus C 3-allyl-5,8-dichloro-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
0.0015
-
-
 Hepacivirus C 3-butyl-8-cyano-7-fluoro-5-methyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
0.0018
-
-
 Hepacivirus C 8-cyano-7-fluoro-5-methyl-3-propyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
0.0019
-
-
 Hepacivirus C 3-butyl-5,8-dichloro-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
0.0021
-
-
 Hepacivirus C (5-cyano-8-methyl-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
0.0021
-
-
 Hepacivirus C (5-cyano-8-fluoro-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
0.0023
-
-
 Hepacivirus C (5,8-dicyano-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
0.0032
-
-
 Hepacivirus C 5,8-dichloro-1-propyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid
0.0046
-
-
 Hepacivirus C 3-butyl-8-cyano-5-methyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
0.0047
-
-
 Hepacivirus C 8-cyano-5-methyl-3-propyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
0.0054
-
-
 Hepacivirus C 3-butyl-8-cyano-5-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
0.0058
-
-
 Hepacivirus C 8-chloro-1-propyl-5-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid
0.0063
-
-
 Hepacivirus C 3-allyl-8-cyano-7-fluoro-5-methyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
0.0081
-
-
 Hepacivirus C 8-cyano-5-fluoro-3-propyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
0.01
-
-
 Hepacivirus C 5-cyano-8-fluoro-1-propyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid
0.011
-
-
 Hepacivirus C 3-allyl-8-cyano-5-methyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
0.0145
-
-
 Hepacivirus C 3-allyl-8-cyano-5-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
0.015
-
-
 Hepacivirus C 5-cyano-8-methyl-1-propyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid
0.03
-
-
 Hepacivirus C (5,7-difluoro-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid