Literature summary for 2.7.7.48 extracted from

Kanamori, H.; Yuhashi, K.; Ohnishi, S.; Koike, K.; Kodama, T.
RNA dependent RNA polymerase of hepatitis C virus binds to its coding region RNA stem-loop structure, 5BSL3.2, and its negative strand (2010), J. Gen. Virol., 91, 1207-1212.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5BSL3.2N	the complementary strand of 5BSL3.2 inhibits the enzyme, the bulge structure is indispensable for enzyme binding	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	NS5B	-
Hepacivirus C NS5B	-	NS5B	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the viral enzyme binds to its coding region RNA stem-loop structure, 5BSL3.2, and its negative strand, enzyme and RNA interaction is an important step in viral RNA replication, overview	Hepacivirus C	?	-	?
additional information	the viral enzyme binds to its coding region RNA stem-loop structure, 5BSL3.2, and its negative strand, enzyme and RNA interaction is an important step in viral RNA replication, overview	Hepacivirus C NS5B	?	-	?

Synonyms

Synonyms	Comment	Organism
NS5B RdRp	-	Hepacivirus C
RDRP	-	Hepacivirus C
RNA dependent RNA polymerase	-	Hepacivirus C

General Information

General Information	Comment	Organism
metabolism	key enzyme involved in vrial replication	Hepacivirus C

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Release 2023.1 (January 2023)