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Literature summary for 2.7.7.48 extracted from
- Mitochondrion-enriched anionic phospholipids facilitate flock house virus RNA polymerase membrane association (2009), J. Virol., 83, 4498-4507.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Flock house virus | enzyme-host membrane interactions are an initial step of FHV RNA replication complex assembly, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Flock house virus | - |
i.e. FHV | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | the viral replication complex assembles on the host mitochondrial outer membrane, the enzyme preferentially binds to specific anionic phospholipids, in particular the mitochondrion-specific phospholipid cardiolipin | Flock house virus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme-host membrane interactions are an initial step of FHV RNA replication complex assembly, overview | Flock house virus | ? | - |
? | |
| additional information | the enzyme translates in vitro rapidly. It specifically associates with mitochondria isolated from yeast, insect, and mammalian cells, temperature-dependently but independent of protease-sensitive mitochondrial outer membrane components or the host mitochondrial import machinery. The enzyme preferentially binds to specific anionic phospholipids, in particular the mitochondrion-specific phospholipid cardiolipin | Flock house virus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RNA polymerase | - |
Flock house virus |
| RNA-dependent RNA polymerase | - |
Flock house virus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the FHV RNA-dependent RNA polymerase, protein A, is the only viral protein necessary for genome replication in the budding yeast Saccharomyces cerevisiae | Flock house virus |
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Release 2023.1 (January 2023)
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