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Literature summary for 2.7.7.48 extracted from

  • Noble, C.G.; Lim, S.P.; Chen, Y.L.; Liew, C.W.; Yap, L.; Lescar, J.; Shi, P.Y.
    Conformational flexibility of the dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor (2013), J. Virol., 87, 5291-5295.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
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Dengue virus type 3

Crystallization (Commentary)

Crystallization (Comment) Organism
native and in complex with inhibitor 5-[[(4-chlorophenyl)sulfonyl]amino]-2-methyl-1-benzofuran-3-carboxylic acid, to 1.79 and 2.1 A resolution, respectively. The inhibitor binds to the protein as a dimer and causes conformational changes in the protein Dengue virus type 3

Inhibitors

Inhibitors Comment Organism Structure
5-[[(4-chlorophenyl)sulfonyl]amino]-2-methyl-1-benzofuran-3-carboxylic acid crystallization data, the inhibitor binds to the protein as a dimer and causes conformational changes in the protein Dengue virus type 3

Organism

Organism UniProt Comment Textmining
Dengue virus type 3 Q6DLV0 viral polyprotein
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