Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-catechin | - |
Moloney murine leukemia virus | |
(+)-taxifolin | - |
Moloney murine leukemia virus | |
(-)-epicatechin | - |
Moloney murine leukemia virus | |
fisetin | - |
Moloney murine leukemia virus | |
flavanonol | low inhibition | Moloney murine leukemia virus | |
flavone | low inhibition | Moloney murine leukemia virus | |
flavonol | - |
Moloney murine leukemia virus | |
kaempferol | - |
Moloney murine leukemia virus | |
additional information | simultaneous presence of free hydroxyl groups at position 3 and 4' enhance the reverse transcriptase inhibitory activity. Replacement of the 3-hydroxyl group with a monosaccharide or of the 4'-hydroxyl group with a Me group reduces inhibitory activity. The double bond at position 2 and 3 of the flavonoids pyrone ring is not essential for inhibiting reverse transcriptase activity | Moloney murine leukemia virus | |
morin | - |
Moloney murine leukemia virus | |
myricetin | - |
Moloney murine leukemia virus | |
quercetin | - |
Moloney murine leukemia virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Moloney murine leukemia virus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | - |
Moloney murine leukemia virus | diphosphate + DNAn+1 | - |
? |