Literature summary for 2.7.7.49 extracted from

Pandey, M.; Patel, S.; Gabriel, A.
Insights into the role of an active site aspartate in Ty1 reverse transcriptase polymerization (2004), J. Biol. Chem., 279, 47840-47848.

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Protein Variants

Protein Variants	Comment	Organism
D211N	still capable of in vitro polymerization, although it is blocked for in vivo transposition. D211N mutation has minimal effect on nucleotide binding but reduces the kpol by about 230fold. The mutation reduces binding affinity for both Mn2+ and Mg2+	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	mutant version of reverse trancriptase from retrotransposon Ty1, in which one of the three active site aspartates is changed to asparagine, D211N	-

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Release 2023.1 (January 2023)