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Literature summary for 2.7.7.49 extracted from

  • El Safadi, Y.; Vivet-Boudou, V.; Marquet, R.
    HIV-1 reverse transcriptase inhibitors (2007), Appl. Microbiol. Biotechnol., 75, 723-737.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(+)-Calanolide A
-
Human immunodeficiency virus 1
2',3'-dideoxycytidine
-
Human immunodeficiency virus 1
2',3'-dideoxyinosine
-
Human immunodeficiency virus 1
3'-azido-3'-deoxythymidine
-
Human immunodeficiency virus 1
3'-gluoro-5'-(2-valyloxypropanoyl)-2',3'-dideoxyguanosine
-
Human immunodeficiency virus 1
355-BS
-
Human immunodeficiency virus 1
4'E-d2-FA
-
Human immunodeficiency virus 1
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
-
Human immunodeficiency virus 1
Abacavir
-
Human immunodeficiency virus 1
Amdoxovir
-
Human immunodeficiency virus 1
Apricitabine
-
Human immunodeficiency virus 1
d4T-Monophosphate
-
Human immunodeficiency virus 1
Delavirdine
-
Human immunodeficiency virus 1
Dioxolan Thymidine
-
Human immunodeficiency virus 1
efavirenz
-
Human immunodeficiency virus 1
Elvucitabine
-
Human immunodeficiency virus 1
Emtricitabine
-
Human immunodeficiency virus 1
Etravirine
-
Human immunodeficiency virus 1
lamivudine
-
Human immunodeficiency virus 1
additional information inhibitors of reverse transcriptase belong to two main classes acting by distinct mechanisms. Nucleoside inhibitors of reverse transcriptase lack a 3' hydroxyl group on their ribose or ribose mimic moiety and thus act as chain terminators. Non-nucleoside inhibitors of reverse transcriptase bind into a hydrophobic pocket close to the polymerase active site and inhibit the chemical step of the polymerization reaction Human immunodeficiency virus 1
nevirapine
-
Human immunodeficiency virus 1
Rilpivirine
-
Human immunodeficiency virus 1
Stampidine
-
Human immunodeficiency virus 1
stavudine
-
Human immunodeficiency virus 1
Tenofovir
-
Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn reverse transcriptase has RNA-dependent and DNA-dependent DNA polymerase activity Human immunodeficiency virus 1 diphosphate + DNAn+1
-
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