Literature summary for 2.7.7.49 extracted from

Herschhorn, A.; Lerman, L.; Weitman, M.; Gleenberg, I.O.; Nudelman, A.; Hizi, A.
De novo parallel design, synthesis and evaluation of inhibitors against the reverse transcriptase of human immunodeficiency virus type-1 and drug-resistant variants (2007), J. Med. Chem., 50, 2370-2384.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-amino-4-(3-benzoylphenyl)thiazole-5-carboxamide	-	Human immunodeficiency virus 1
2-amino-4-(3-bromo-4-chlorophenyl)thiazole-5-carboxamide	-	Human immunodeficiency virus 1
2-amino-4-(3-chlorophenyl)thiazole-5-carboxamide	-	Human immunodeficiency virus 1
2-amino-4-(3-iodophenyl)thiazole-5-carboxamide	-	Human immunodeficiency virus 1
2-amino-4-(3-phenylphenyl)thiazole-5-carboxamide	-	Human immunodeficiency virus 1
2-amino-4-phenylthiazole-5-carboxamide	-	Human immunodeficiency virus 1
3-(2-cyanoacetyl)phenyl diethyl phosphate	-	Human immunodeficiency virus 1
3-(3-chlorophenyl)-3-oxopropanenitrile	-	Human immunodeficiency virus 1
3-(3-iodophenyl)-3-oxopropanamide	-	Human immunodeficiency virus 1
3-benzoyl-3-oxopropanenitrile	-	Human immunodeficiency virus 1
3-phenyl-3-oxopropanenitrile	-	Human immunodeficiency virus 1
4-(3-benzoylphenyl)thiazole-5-carboxamide	-	Human immunodeficiency virus 1
4-(3-bromo-4-chlorophenyl)-1H-imidazole-5-carboxamide	-	Human immunodeficiency virus 1
4-(3-bromo-4-chlorophenyl)thiazole-5-carboxamide	-	Human immunodeficiency virus 1
4-(3-chlorophenyl)-1H-imidazole-5-carboxamide	-	Human immunodeficiency virus 1
4-(3-iodophenyl)-3-oxobutanenitrile	-	Human immunodeficiency virus 1
4-phenyl-1H-imidazole-5-carboxamide	-	Human immunodeficiency virus 1
4-phenylthiazole-5-carboxamide	-	Human immunodeficiency virus 1
nevirapine	-	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	P04585	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	poly(rA)n¥oligo(dT)12-18	Human immunodeficiency virus 1	diphosphate + DNAn+1	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0017	-	-	Human immunodeficiency virus 1	nevirapine
0.0035	-	-	Human immunodeficiency virus 1	4-(3-iodophenyl)-3-oxobutanenitrile
0.0041	-	-	Human immunodeficiency virus 1	3-(3-chlorophenyl)-3-oxopropanenitrile
0.0098	-	-	Human immunodeficiency virus 1	3-benzoyl-3-oxopropanenitrile
0.0099	-	-	Human immunodeficiency virus 1	4-(3-bromo-4-chlorophenyl)-1H-imidazole-5-carboxamide
0.0163	-	-	Human immunodeficiency virus 1	4-(3-benzoylphenyl)thiazole-5-carboxamide
0.0296	-	-	Human immunodeficiency virus 1	3-(3-iodophenyl)-3-oxopropanamide
0.0334	-	-	Human immunodeficiency virus 1	3-phenyl-3-oxopropanenitrile
0.0441	-	-	Human immunodeficiency virus 1	2-amino-4-(3-benzoylphenyl)thiazole-5-carboxamide
0.0544	-	-	Human immunodeficiency virus 1	2-amino-4-(3-chlorophenyl)thiazole-5-carboxamide
0.0592	-	-	Human immunodeficiency virus 1	2-amino-4-(3-phenylphenyl)thiazole-5-carboxamide
0.0643	-	-	Human immunodeficiency virus 1	3-(2-cyanoacetyl)phenyl diethyl phosphate
0.0798	-	-	Human immunodeficiency virus 1	4-(3-chlorophenyl)-1H-imidazole-5-carboxamide
0.0807	-	-	Human immunodeficiency virus 1	2-amino-4-phenylthiazole-5-carboxamide
0.0875	-	-	Human immunodeficiency virus 1	4-(3-bromo-4-chlorophenyl)thiazole-5-carboxamide
0.118	-	-	Human immunodeficiency virus 1	2-amino-4-(3-bromo-4-chlorophenyl)thiazole-5-carboxamide
0.1254	-	-	Human immunodeficiency virus 1	2-amino-4-(3-iodophenyl)thiazole-5-carboxamide
0.283	-	-	Human immunodeficiency virus 1	4-phenylthiazole-5-carboxamide
0.3	-	-	Human immunodeficiency virus 1	4-phenyl-1H-imidazole-5-carboxamide

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Release 2023.1 (January 2023)