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Literature summary for 2.7.7.49 extracted from

  • Bauman, J.D.; Das, K.; Ho, W.C.; Baweja, M.; Himmel, D.M.; Clark, A.D.; Oren, D.A.; Boyer, P.L.; Hughes, S.H.; Shatkin, A.J.; Arnold, E.
    Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design (2008), Nucleic Acids Res., 36, 5083-5092.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Human immunodeficiency virus 1

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitor TMC278, hanging drop vapour diffusion method, using 9% to 12% PEG 8000, 50 mM imidazole pH 6.0-6.8, 10 mM spermine, 15 mM MgSO4 and 100 mM ammonium sulfate Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
Etravirine
-
Human immunodeficiency virus 1
Rilpivirine
-
Human immunodeficiency virus 1
TMC125
-
Human immunodeficiency virus 1
TMC278 nonnucleoside reverse transcriptase inhibitor Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1 P03366
-
-

Purification (Commentary)

Purification (Comment) Organism
Mono Q column chromatography Human immunodeficiency virus 1

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Human immunodeficiency virus 1 diphosphate + DNAn+1
-
?

Synonyms

Synonyms Comment Organism
reverse transcriptase
-
Human immunodeficiency virus 1