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Literature summary for 2.7.7.49 extracted from
- Synthesis and anti-HIV activities of symmetrical dicarboxylate esters of dinucleoside reverse transcriptase inhibitors (2012), Bioorg. Med. Chem. Lett., 22, 5451-5454.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (R)-9-(2-phosphonomethoxypropyl)adenine | - |
Human immunodeficiency virus 1 |  |
| 1,10-di-2',3'-dideoxy-3'-thiacytidine-decanoate | - |
Human immunodeficiency virus 1 | |
| 1,10-di-3'-azido-2',3'-dideoxythymidine-decanoate | - |
Human immunodeficiency virus 1 | |
| 1,10-di-3'-fluoro-2',3'-dideoxythymidine-decanoate | - |
Human immunodeficiency virus 1 | |
| 1,12-di-2',3'-dideoxy-3'-thiacytidine-dodecanoate | - |
Human immunodeficiency virus 1 | |
| 1,12-di-3'-azido-2',3'-dideoxythymidine-dodecanoate | - |
Human immunodeficiency virus 1 | |
| 1,12-di-3'-fluoro-2',3'-dideoxythymidine-dodecanoate | - |
Human immunodeficiency virus 1 | |
| 1,14-di-2',3'-dideoxy-3'-thiacytidine-tetradecanoate | - |
Human immunodeficiency virus 1 | |
| 1,14-di-3'-azido-2',3'-dideoxythymidine-tetradecanoate | - |
Human immunodeficiency virus 1 | |
| 1,14-di-3'-fluoro-2',3'-dideoxythymidine-tetradecanoate | - |
Human immunodeficiency virus 1 | |
| 1,4-di-2',3'-dideoxy-3'-thiacytidine-succinate | - |
Human immunodeficiency virus 1 | |
| 2',3'-didehydro-2',3'-dideoxythymidine | - |
Human immunodeficiency virus 1 | |
| 2',3'-dideoxy-3'-thiacytidine | - |
Human immunodeficiency virus 1 | |
| 2',3'-dideoxy-5-fluoro-3'-thiacytidine | - |
Human immunodeficiency virus 1 | |
| 2',3'-dideoxycytidine | - |
Human immunodeficiency virus 1 | |
| 3'-azido-2',3'-dideoxythymidine | - |
Human immunodeficiency virus 1 | |
| 3'-azido-3'-deoxythymidine | - |
Human immunodeficiency virus 1 | |
| 3'-fluoro-2',3'-dideoxythymidine | - |
Human immunodeficiency virus 1 | |
| additional information | inhibitor structure-activity relationships, overview | Human immunodeficiency virus 1 |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human immunodeficiency virus 1 | - |
- |
- |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00000076 | - |
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,14-di-3'-fluoro-2',3'-dideoxythymidine-tetradecanoate | |
| 0.00000097 | - |
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,12-di-3'-fluoro-2',3'-dideoxythymidine-dodecanoate | |
| 0.000001 | - |
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,10-di-3'-fluoro-2',3'-dideoxythymidine-decanoate | |
| 0.000002 | - |
enzyme from HIV-1 III B, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-azido-2',3'-dideoxythymidine | |
| 0.000002 | - |
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-fluoro-2',3'-dideoxythymidine | |
| 0.000002 | - |
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,12-di-3'-azido-2',3'-dideoxythymidine-dodecanoate | |
| 0.000003 | - |
enzyme from HIV-1 III B, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,14-di-3'-fluoro-2',3'-dideoxythymidine-tetradecanoate | |
| 0.000003 | - |
enzyme from HIV-1 III B, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,14-di-3'-azido-2',3'-dideoxythymidine-tetradecanoate | |
| 0.000003 | - |
enzyme from HIV-1 III B, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,14-di-2',3'-dideoxy-3'-thiacytidine-tetradecanoate | |
| 0.000003 | - |
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,14-di-3'-azido-2',3'-dideoxythymidine-tetradecanoate | |
| 0.000004 | - |
enzyme from HIV-1 III B, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,10-di-3'-fluoro-2',3'-dideoxythymidine-decanoate | |
| 0.000004 | - |
enzyme from HIV-1 III B, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,12-di-3'-fluoro-2',3'-dideoxythymidine-dodecanoate | |
| 0.000004 | - |
enzyme from HIV-1 III B, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,12-di-3'-azido-2',3'-dideoxythymidine-dodecanoate | |
| 0.000004 | - |
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,10-di-3'-azido-2',3'-dideoxythymidine-decanoate | |
| 0.000005 | - |
enzyme from HIV-1 III B, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,10-di-3'-azido-2',3'-dideoxythymidine-decanoate | |
| 0.000008 | - |
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-azido-2',3'-dideoxythymidine | |
| 0.000009 | - |
enzyme from HIV-1 III B, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,12-di-2',3'-dideoxy-3'-thiacytidine-dodecanoate | |
| 0.00002 | - |
enzyme from HIV-1 III B, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-fluoro-2',3'-dideoxythymidine | |
| 0.00002 | - |
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,12-di-2',3'-dideoxy-3'-thiacytidine-dodecanoate | |
| 0.00003 | - |
enzyme from HIV-1 III B, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,10-di-2',3'-dideoxy-3'-thiacytidine-decanoate | |
| 0.00003 | - |
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,14-di-2',3'-dideoxy-3'-thiacytidine-tetradecanoate | |
| 0.00006 | - |
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,10-di-2',3'-dideoxy-3'-thiacytidine-decanoate | |
| 0.00009 | - |
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 2',3'-dideoxy-3'-thiacytidine | |
| 0.00013 | - |
enzyme from HIV-1 III B, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,4-di-2',3'-dideoxy-3'-thiacytidine-succinate | |
| 0.00015 | - |
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,4-di-2',3'-dideoxy-3'-thiacytidine-succinate | |
| 0.0002 | - |
enzyme from HIV-1 III B, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 2',3'-dideoxy-3'-thiacytidine | |
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