Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
kinetoplast | - |
Trypanosoma brucei | 20023 | - |
mitochondrion | 2 isozymes RET1 and RET2 in mitochondria editosomes | Trypanosoma brucei | 5739 | - |
additional information | isozymes are located in 2 different complexes | Trypanosoma brucei | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Trypanosoma brucei | reduction of isozyme RET1 leads to decrease in edited RNA and inhibited growth, lowers the uridine insertion and leads predominantly to shorter gRNAs | ? | - |
? | |
additional information | Trypanosoma brucei | down-regulation of isozyme RET2 inhibits growth and in vivo uridine insertion, but has no effect on the length of gRNAs | ? | - |
? | |
additional information | Trypanosoma brucei | many editing changes are developmentally regulated | ? | - |
? | |
UTP + RNAn | Trypanosoma brucei | involved in uridine insertion in the editing process of RNA | diphosphate + RNAn+1 | - |
? | |
UTP + RNAn | Trypanosoma brucei | responsible for post-transcriptional RNA editing process of mitochondrial transcripts in kinetoplastid protozoans | diphosphate + RNAn+1 | - |
? | |
UTP + RNAn | Trypanosoma brucei | addition of non-coded poly(U) tail to gRNAs | diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
RET1 and RET2, i.e. RNA editing TUTases 1 and 2, as components of different editing complexes | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
UTP + RNAn = diphosphate + RNAn+3'-U | mechanism, uridine insertion in the editing process | Trypanosoma brucei |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | reduction of isozyme RET1 leads to decrease in edited RNA and inhibited growth, lowers the uridine insertion and leads predominantly to shorter gRNAs | Trypanosoma brucei | ? | - |
? | |
additional information | down-regulation of isozyme RET2 inhibits growth and in vivo uridine insertion, but has no effect on the length of gRNAs | Trypanosoma brucei | ? | - |
? | |
additional information | many editing changes are developmentally regulated | Trypanosoma brucei | ? | - |
? | |
UTP + RNAn | kinetoplast RNA | Trypanosoma brucei | diphosphate + RNAn+1 | - |
? | |
UTP + RNAn | involved in uridine insertion in the editing process of RNA | Trypanosoma brucei | diphosphate + RNAn+1 | - |
? | |
UTP + RNAn | responsible for post-transcriptional RNA editing process of mitochondrial transcripts in kinetoplastid protozoans | Trypanosoma brucei | diphosphate + RNAn+1 | - |
? | |
UTP + RNAn | addition of non-coded poly(U) tail to gRNAs | Trypanosoma brucei | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RET | i.e. RNA editing TUTase | Trypanosoma brucei |