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Literature summary for 2.7.7.52 extracted from

  • Thornton, J.E.; Chang, H.M.; Piskounova, E.; Gregory, R.I.
    Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7) (2012), RNA, 18, 1875-1885.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine a single C2H2-type zinc finger domain of Zcchc11 is responsible for the functional interaction with pluripotency factor Lin28. Lin28 uses terminal uridylyltransferases Zcchc11 and Zcchc6 to control let-7 expression and has important implications for stem cell biology as well as cancer Homo sapiens
medicine pluripotency factor Lin28 uses terminal uridylyltransferases Zcchc11 and Zcchc6 to control let-7 expression and has important implications for stem cell biology as well as cancer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5TAX3 isoform Zcchc11, TUT4
-
Homo sapiens Q5VYS8 isoform Zcchc6, TUT7
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
More a single C2H2-type zinc finger domain of Zcchc11 is responsible for the functional interaction with pluripotency factor Lin28. Lin28 uses terminal uridylyltransferases Zcchc11 and Zcchc6 to control let-7 expression and has important implications for stem cell biology as well as cancer Homo sapiens

Synonyms

Synonyms Comment Organism
TUT4
-
 Homo sapiens
TUT7
-
 Homo sapiens
TUTase
-
 Homo sapiens
Zcchc11
-
 Homo sapiens
ZCCHC6
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function isoforms Zcchc11 and Zcchc6 redundantly control let-7 biogenesis in embryonic stem cells Homo sapiens