Literature summary for 2.7.7.6 extracted from

Temiakov, D.; Patlan, V.; Anikin, M.; McAllister, W.T.; Yokoyama, S.; Vassylyev, D.G.
Structural basis for substrate selection by T7 RNA polymerase (2004), Cell, 116, 381-391.

Search for more literature for 2.7.7.6

Crystallization (Commentary)

Crystallization (Comment)	Organism
T7 RNAP elonation complex	Escherichia phage T7

Organism

Organism	UniProt	Comment	Textmining
Escherichia phage T7	P00573	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	substrate specifically binds to the enzyme in the open conformation, where it is base paired with the acceptor template base, while Tyr639 provides discrimination of ribose versus deoxyribose substrates. Substrate selection occurs prior to the isomerization to the catalytically active conformation	Escherichia phage T7	diphosphate + RNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
T7 RNAP	-	Escherichia phage T7

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Release 2023.1 (January 2023)