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Literature summary for 2.7.7.6 extracted from

  • Sousa, R.
    Tie me up, tie me down: inhibiting RNA polymerase (2008), Cell, 135, 205-207.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development the enzyme is a target for drug design Thermus thermophilus

Inhibitors

Inhibitors Comment Organism Structure
myxopyronin produced by the bacteria Myxococcus fulvus, inhibits initiation of RNA polymerase transcription and binding complex structure. The compounds inhibits the enzyme also from rifamycin- or multidrug-resistant bacteria. the inhibition mechanism proceeds via inhibiting DNA binding rather than affecting transcription complex stability or processivity following DNA binding, overview Thermus thermophilus
rifamycin
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Thermus thermophilus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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Saccharomyces cerevisiae 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae RNAPII recruits COMPASS, a histone methyltransferase, as well as the regulator Paf1C, to the transcription active site causing methylation of histone H3K4 in a transcription-dependent manner. The large RNAPII subunit Rpb1 attracts FACT, a transcription factor that FACT participates in regulation of DNA repair and replication, to the transcription site, and Rpb1 also interacts with RSC, an abundant Swi/Snf-like chromatin remodeling complex with multiple subunits, and other general transcription factors, as well as with histone chaperone proteins, mRNA processing and export factors, DNA repair factors, protein kinases, and other cellular proteins, overview ?
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?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Thermus thermophilus
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RNAPII recruits COMPASS, a histone methyltransferase, as well as the regulator Paf1C, to the transcription active site causing methylation of histone H3K4 in a transcription-dependent manner. The large RNAPII subunit Rpb1 attracts FACT, a transcription factor that FACT participates in regulation of DNA repair and replication, to the transcription site, and Rpb1 also interacts with RSC, an abundant Swi/Snf-like chromatin remodeling complex with multiple subunits, and other general transcription factors, as well as with histone chaperone proteins, mRNA processing and export factors, DNA repair factors, protein kinases, and other cellular proteins, overview Saccharomyces cerevisiae ?
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?

Subunits

Subunits Comment Organism
More analysis of interaction sbetween the largest subunit Rpb1 and the other subunits, overview Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
RNA polymerase
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Thermus thermophilus
RNA polymerase II
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Saccharomyces cerevisiae
RNAP
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Thermus thermophilus
RNAPII
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Saccharomyces cerevisiae