Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | RNA polymerase complex with associated proteins, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | RNA polymerase II phosphorylation during paused, active and poised transcription cycles with in itiation and elongation stages and at different phosphorylation stages, RNA polymerase II and histone modification profiles across genes in paused, active and poised states, and RNAPII regulation mechanisms at active genes, detailed overview. In embryonic stem cells, silent developmental regulator genes that are repressed by Polycomb are associated with a form of RNAPII that can elongate through coding regions but that lacks the post-translational modifications that are important for coupling RNA synthesis to co-transcriptional maturation | ? | - |
? | |
nucleoside triphosphate + RNAn | Homo sapiens | RNAPIIis recruited to gene promoters in a hypo-phosphorylated state | diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | in embryonic stem cells, silent developmental regulator genes that are repressed by Polycomb are associated with a form of RNAPII that can elongate through coding regions but that lacks the post-translational modifications that are important for coupling RNA synthesis to co-transcriptional maturation | Homo sapiens |
phosphoprotein | RNAPIIis recruited to gene promoters in a hypophosphorylated state, but is phosphorylated at Ser5, Ser7, and Ser2. Its escape from the promoter requires TFIIH-mediated phosphorylation of Ser5, the onset of productive elongation requires P-TEFb, which phosphorylates Ser2 residues of the RNAPII C-terminal domain to produce stable elongation complexes. Absence of Ser 2Pat poised RNAPIIcomplexes is likely to disrupt co-transcriptional RNAmaturation and histone modification to help maintain the silent state, whereas binding and transcription by RNAPII counteract Polycomb-mediated chromatin condensation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic stem cell | in embryonic stem cells, silent developmental regulator genes that are repressed by Polycomb are associated with a form of RNAPII that can elongate through coding regions but that lacks the post-translational modifications that are important for coupling RNA synthesis to co-transcriptional maturation | Homo sapiens | - |
additional information | RNAPII complexes are also located at silent genes in promoter-proximal paused configurations that provide dynamic transcriptional regulation downstream from initiation | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | RNA polymerase II phosphorylation during paused, active and poised transcription cycles with in itiation and elongation stages and at different phosphorylation stages, RNA polymerase II and histone modification profiles across genes in paused, active and poised states, and RNAPII regulation mechanisms at active genes, detailed overview. In embryonic stem cells, silent developmental regulator genes that are repressed by Polycomb are associated with a form of RNAPII that can elongate through coding regions but that lacks the post-translational modifications that are important for coupling RNA synthesis to co-transcriptional maturation | Homo sapiens | ? | - |
? | |
nucleoside triphosphate + RNAn | RNAPIIis recruited to gene promoters in a hypo-phosphorylated state | Homo sapiens | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RNA polymerase II | - |
Homo sapiens |
RNAPII | - |
Homo sapiens |