Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | interaction of elongation factors with RNAP, such as NusG and RfaH, affects the frequency and duration of pausing during transcription | Bacillus subtilis | |
additional information | interaction of elongation factors with RNAP, such as NusG and RfaH, affects the frequency and duration of pausing during transcription | Escherichia coli | |
Rho | in response to the Rho termination factor, RNA synthesis ceases and the completed transcript is released | Bacillus subtilis | |
Rho | in response to the Rho termination factor, RNA synthesis ceases and the completed transcript is released | Escherichia coli | |
sigma factor | a dissociable specificity sigma factor, regulated by factors such as anti-sigma factors, which can sequester r factors and prevent core association, and possibly by factors that enhance sigma-core association | Escherichia coli | |
sigma factor | a dissociable specificity sigma factor, regulated by factors such as anti-sigma factors, which can sequester sigma factors and prevent core association, and possibly by factors that enhance sigma-core association | Bacillus subtilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | Bacillus subtilis | RNAP is an exceptionally complex enzyme that can be thought of as the engine of gene expression, synthesis of RNA transcripts of many thousands of nucleotides without dissociation. Energy, in the form of nucleoside triphosphates, fuels the synthesis of an RNA polymer complementary to specific regions of the DNA template. Like all macromolecular synthesis, RNA synthesis can be divided into three general phases: initiation, elongation, and termination. Importantly, each of these phases can be a target of regulation. Promoter recognition, binding at the extended promoter recognition region, and transcript initiation, RNAP prefers to initiate transcription within a narrow window located between 6 and 9 bp downstream of the -10 element, promoter clearance and elongation, termination and recycling, mechanisms and regulation , overview. The process of start site selection can be governed by the availability of either the +1 or the +2 NTP, depending on the promoter | diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | Escherichia coli | RNAP is an exceptionally complex enzyme that can be thought of as the engine of gene expression, synthesis of RNA transcripts of many thousands of nucleotides without dissociation. Energy, in the form of nucleoside triphosphates, fuels the synthesis of an RNA polymer complementary to specific regions of the DNA template. Like all macromolecular synthesis, RNA synthesis can be divided into three general phases: initiation, elongation, and termination. Importantly, each of these phases can be a target of regulation. Promoter recognition, binding at the extended promoter recognition region, and transcript initiation, RNAP prefers to initiate transcription within a narrow window located between 6 and 9 bp downstream of the -10 element, promoter clearance and elongation, termination and recycling, mechanisms and regulation , overview. The process of start site selection can be governed by the availability of either the +1 or the +2 NTP, depending on the promoter | diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus subtilis | - |
- |
- |
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | - |
Bacillus subtilis | diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | - |
Escherichia coli | diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | RNAP is an exceptionally complex enzyme that can be thought of as the engine of gene expression, synthesis of RNA transcripts of many thousands of nucleotides without dissociation. Energy, in the form of nucleoside triphosphates, fuels the synthesis of an RNA polymer complementary to specific regions of the DNA template. Like all macromolecular synthesis, RNA synthesis can be divided into three general phases: initiation, elongation, and termination. Importantly, each of these phases can be a target of regulation. Promoter recognition, binding at the extended promoter recognition region, and transcript initiation, RNAP prefers to initiate transcription within a narrow window located between 6 and 9 bp downstream of the -10 element, promoter clearance and elongation, termination and recycling, mechanisms and regulation , overview. The process of start site selection can be governed by the availability of either the +1 or the +2 NTP, depending on the promoter | Bacillus subtilis | diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | RNAP is an exceptionally complex enzyme that can be thought of as the engine of gene expression, synthesis of RNA transcripts of many thousands of nucleotides without dissociation. Energy, in the form of nucleoside triphosphates, fuels the synthesis of an RNA polymer complementary to specific regions of the DNA template. Like all macromolecular synthesis, RNA synthesis can be divided into three general phases: initiation, elongation, and termination. Importantly, each of these phases can be a target of regulation. Promoter recognition, binding at the extended promoter recognition region, and transcript initiation, RNAP prefers to initiate transcription within a narrow window located between 6 and 9 bp downstream of the -10 element, promoter clearance and elongation, termination and recycling, mechanisms and regulation , overview. The process of start site selection can be governed by the availability of either the +1 or the +2 NTP, depending on the promoter | Escherichia coli | diphosphate + RNAn+1 | - |
? |
Subunits | Comment | Organism |
---|---|---|
multimer | bacterial RNAP is a multisubunit enzyme and consists of a core polymerase containing the beta, beta' , and two alpha subunits, together with one or more omega subunits, and a dissociable specificity factor sigma | Bacillus subtilis |
multimer | bacterial RNAP is a multisubunit enzyme and consists of a core polymerase containing the beta, beta' , and two alpha subunits, together with one or more omega subunits, and a dissociable specificity factor sigma | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
RNA polymerase | - |
Bacillus subtilis |
RNA polymerase | - |
Escherichia coli |
RNAP | - |
Bacillus subtilis |
RNAP | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | RNAP is an exceptionally complex enzyme that can be thought of as the engine of gene expression | Bacillus subtilis |
physiological function | RNAP is an exceptionally complex enzyme that can be thought of as the engine of gene expression | Escherichia coli |