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Literature summary for 2.7.7.7 extracted from
- DNA polymerase alpha (1989), J. Biol. Chem., 264, 4265-4268.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Polymerase alpha accessory factors | overview | Drosophila melanogaster | |
| Polymerase alpha accessory factors | overview | Mammalia | |
| Polymerase alpha accessory factors | overview | Mus musculus | |
| Polymerase alpha accessory factors | overview | Homo sapiens | |
| Polymerase alpha accessory factors | overview | Saccharomyces cerevisiae | |
| Polymerase alpha accessory factors | overview | Bos taurus | |
| Polymerase alpha accessory factors | overview | Chlorocebus aethiops |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aphidicolin | polymerase alpha and delta | Bos taurus |  |
| aphidicolin | - |
Drosophila melanogaster | |
| aphidicolin | - |
Homo sapiens | |
| aphidicolin | - |
Mammalia | |
| aphidicolin | - |
Mus musculus | |
| aphidicolin | - |
Saccharomyces cerevisiae | |
| N-ethylmaleimide | polymerase alpha and delta | Bos taurus | |
| N-ethylmaleimide | - |
Drosophila melanogaster | |
| N-ethylmaleimide | - |
Homo sapiens | |
| N-ethylmaleimide | - |
Mammalia | |
| N-ethylmaleimide | - |
Mus musculus | |
| N-ethylmaleimide | - |
Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | Drosophila melanogaster | - |
diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | Mammalia | - |
diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | Mus musculus | - |
diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | Homo sapiens | - |
diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | Saccharomyces cerevisiae | - |
diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | Bos taurus | - |
diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | Chlorocebus aethiops | - |
diphosphate + DNAn+1 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II | - |
| Chlorocebus aethiops | - |
monkey | - |
| Drosophila melanogaster | - |
- |
- |
| Homo sapiens | - |
5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II | - |
| Mammalia | - |
- |
- |
| Mus musculus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| CV-1 cell | - |
Chlorocebus aethiops | - |
| HeLa cell | - |
Homo sapiens | - |
| hybridoma cell | - |
Mus musculus | - |
| KB cell | - |
Homo sapiens | - |
| thymus | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | - |
Drosophila melanogaster | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Mammalia | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Mus musculus | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Homo sapiens | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Saccharomyces cerevisiae | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Bos taurus | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Chlorocebus aethiops | diphosphate + DNAn+1 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | subunit structure of DNA polymerase alpha | Drosophila melanogaster |
| More | subunit structure of DNA polymerase alpha | Mammalia |
| More | subunit structure of DNA polymerase alpha | Mus musculus |
| More | subunit structure of DNA polymerase alpha | Homo sapiens |
| More | subunit structure of DNA polymerase alpha | Saccharomyces cerevisiae |
| More | subunit structure of DNA polymerase alpha | Bos taurus |
| More | subunit structure of DNA polymerase alpha | Chlorocebus aethiops |
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