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Literature summary for 2.7.7.7 extracted from

  • Wintersberger E.
    DNA-dependent DNA pllymerases from eukaryotes (1977), Trends Biochem. Sci., 1977, 58-60.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
4-chloromercuribenzoic acid
-
Homo sapiens
4-chloromercuribenzoic acid
-
Saccharomyces cerevisiae
N-ethylmaleimide
-
Bos taurus
N-ethylmaleimide
-
Homo sapiens
N-ethylmaleimide
-
Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm polymerase alpha and gamma Homo sapiens 5737
-
cytoplasm polymerase alpha and gamma Saccharomyces cerevisiae 5737
-
cytoplasm polymerase alpha and gamma Bos taurus 5737
-
mitochondrion
-
Homo sapiens 5739
-
mitochondrion
-
Rattus norvegicus 5739
-
mitochondrion
-
Saccharomyces cerevisiae 5739
-
nucleus DNA polymerase gamma Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
1 * 45000 + 1 * 60000, SDS-PAGE, mitochondrial enzyme Homo sapiens
60000
-
1 * 45000 + 1 * 60000, SDS-PAGE, mitochondrial enzyme Homo sapiens
60000
-
2 * 60000, SDS-PAGE, mitochondrial enzyme Saccharomyces cerevisiae
87000
-
1 * 155000-175000 + 1 * 87000, SDS-PAGE, polymerase alpha Homo sapiens
100000 110000 mitochondrial enzyme Homo sapiens
110000
-
polymerase gamma, HeLa cell line Homo sapiens
120000
-
-
Homo sapiens
120000
-
mitochondrial enzyme Saccharomyces cerevisiae
170000
-
active polymerase alpha Homo sapiens
170000
-
active polymerase alpha Saccharomyces cerevisiae
170000
-
active polymerase alpha Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Homo sapiens
-
diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn Rattus norvegicus
-
diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn Saccharomyces cerevisiae
-
diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn Bos taurus
-
diphosphate + DNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-
KB cell
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
thymus
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Homo sapiens diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn
-
Rattus norvegicus diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn
-
Saccharomyces cerevisiae diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn
-
Bos taurus diphosphate + DNAn+1
-
?

Subunits

Subunits Comment Organism
dimer 1 * 45000 + 1 * 60000, SDS-PAGE, mitochondrial enzyme Homo sapiens
dimer 1 * 155000-175000 + 1 * 80000-90000, SDS-PAGE, polymerase alpha Saccharomyces cerevisiae
dimer 1 * 155000-175000 + 1 * 80000-90000, SDS-PAGE, polymerase alpha Bos taurus
dimer 2 * 60000, SDS-PAGE, mitochondrial enzyme Saccharomyces cerevisiae
dimer 1 * 155000-175000 + 1 * 87000, SDS-PAGE, polymerase alpha Homo sapiens