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Literature summary for 2.7.7.7 extracted from

  • Pisani, F.M.; De Felice, M.; Manco, G.; Rossi, M.
    Domain organization and biochemical features of Sulfolobus solfataricus DNA polymerase (1998), Extremophiles, 2, 171-177.
    View publication on PubMed
Search for more literature for 2.7.7.7

Inhibitors

Inhibitors Comment Organism Structure
aphidicolin
-
 Saccharolobus solfataricus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ enzyme prefers Mg2+ over Mn2+ Saccharolobus solfataricus
Mn2+ enzyme prefers Mg2+ over Mn2+ Saccharolobus solfataricus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110000
-
 gel filtration, glycerol gradient centrifugation Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Saccharolobus solfataricus
-
 diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Saccharolobus solfataricus MT4
-
 diphosphate + DNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus
-
-
-
Saccharolobus solfataricus MT4
-
-
-

Reaction

Reaction Comment Organism Reaction ID
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Saccharolobus solfataricus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Saccharolobus solfataricus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn exonuclease 3'--5' activity Saccharolobus solfataricus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn
-
 Saccharolobus solfataricus MT4 diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn exonuclease 3'--5' activity Saccharolobus solfataricus MT4 diphosphate + DNAn+1
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
75
-
-
 Saccharolobus solfataricus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
65 70 stable for several hours Saccharolobus solfataricus
85
-
 50% loss of activity after 35 min Saccharolobus solfataricus
90
-
 50% loss of activity after 6 min Saccharolobus solfataricus