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Literature summary for 2.7.7.7 extracted from

  • Lebedeva, N.A.; Rechkunova, N.I.; Dezhurov, S.V.; Khodyreva, S.N.; Favre, A.; Blanco, L.; Lavrik, O.I.
    Comparison of functional properties of mammalian DNA polymerase l and DNA polymerase b in reactions of DNA synthesis related to DNA repair (2005), Biochim. Biophys. Acta, 1751, 150-158.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
FEN1 stimulates strand displacement activity, DEN1 processes nicked DNA, thus removing a barrier to Pol lambda DNA synthesis. It results in a one-nucleotide gapped DNA molecule that is a favorite substrate of Pol lambda Homo sapiens
PCNA stimulates strand displacement activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Homo sapiens Pol lambda plays a role in the short-patch base excision repair rather than contributes to the long-patch base excision repair pathway diphosphate + DNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn Pol lambda plays a role in the short-patch base excision repair rather than contributes to the long-patch base excision repair pathway Homo sapiens diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn Pol lambda is unable to catalyze strand displacement synthesis using nicked DNA, although this enzyme efficiently incorporates a dNMP into a one-nucleotide gap Homo sapiens diphosphate + DNAn+1
-
?

Synonyms

Synonyms Comment Organism
DNA polymerase lambda
-
Homo sapiens
Pol lambda
-
Homo sapiens