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Literature summary for 2.7.7.7 extracted from

  • Di Pasquale, F.; Fischer, D.; Grohmann, D.; Restle, T.; Geyer, A.; Marx, A.
    Opposed steric constraints in human DNA polymerase beta and E. coli DNA polymerase I (2008), J. Am. Chem. Soc., 130, 10748-10757.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Escherichia coli diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn
-
Homo sapiens diphosphate + DNAn+1
-
?
additional information Pol beta does incorporate size augmented thymidine analogues besides the unmodified TTP Escherichia coli ?
-
?
additional information Pol beta does not incorporate size augmented thymidine analogues, while the unmodified TTP is processed Homo sapiens ?
-
?
additional information small 4'-methyl and -ethyl modifications of the nucleoside triphosphate do not perturb Klenow fragment catalysis Escherichia coli ?
-
?
additional information while small 4'-methyl and -ethyl modifications of the nucleoside triphosphate perturb Pol beta catalysis, extension of modified primer strands is only marginally affected Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
DNA polymerase beta
-
Homo sapiens
DNA polymerase I
-
Escherichia coli
KF(exo-) 3'->5'-exonuclease-deficient Klenow fragment of DNA polymerase I Escherichia coli
pol beta
-
Homo sapiens
Pol I
-
Escherichia coli