Literature summary for 2.7.7.7 extracted from

Jaiswal, A.S.; Banerjee, S.; Panda, H.; Bulkin, C.D.; Izumi, T.; Sarkar, F.H.; Ostrov, D.A.; Narayan, S.
A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells (2009), Mol. Cancer Res., 7, 1973-1983.

Search for more literature for 2.7.7.7

Inhibitors

Inhibitors	Comment	Organism	Structure
NSC-666715	potent, small molecular weight inhibitor of DNA polymerase beta, blocks Pol-beta-directed single-nucleotide- and long-patch-base excisison repair	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P06746	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colonic adenocarcinoma cell	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Homo sapiens	diphosphate + DNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
DNA polymerase beta	-	Homo sapiens
Pol-beta	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)