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Literature summary for 2.7.7.7 extracted from

  • Betous, R.; Rey, L.; Wang, G.; Pillaire, M.J.; Puget, N.; Selves, J.; Biard, D.S.; Shin-ya, K.; Vasquez, K.M.; Cazaux, C.; Hoffmann, J.S.
    Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells (2009), Mol. Carcinog., 48, 369-378.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.7

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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U2-OS cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn naturally occurring DNA structures are physiological substrates of both pol eta and pol kappa Homo sapiens diphosphate + DNAn+1
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 ?

Synonyms

Synonyms Comment Organism
DNA polymerase eta
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 Homo sapiens
DNA polymerase kappa
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 Homo sapiens
Pol eta
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 Homo sapiens
pol kappa
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 Homo sapiens

General Information

General Information Comment Organism
malfunction the depletion of Pol eta or Pol kappa elevates DNA damage associated with non-plasmid pULCtrl formed at the human c-MYC promoter Homo sapiens
physiological function both Pol eta and Pol kappa prevent genomic instability occurring at natural DNA sequences capable of forming unusual secondary structures in human cells Homo sapiens