Literature summary for 2.7.7.8 extracted from

Sarkar, D.; Lebedeva, I.V.; Emdad, L.; Kang, D.C.; Baldwin, A.S.; Fisher, P.B.
Human polynucleotide phosphorylase (hPNPaseold-35): a potential link between aging and inflammation (2004), Cancer Res., 64, 7473-7478.

Search for more literature for 2.7.7.8

Cloned(Commentary)

Cloned (Comment)	Organism
enhanced expression of hPNPase(old-35) via a replication-incompetent adenovirus (Ad.hPNPase(old-35)) in human melanoma cells and normal melanocytes	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
RNAn+1 + phosphate	Homo sapiens	enhanced expression of hPNPase(old-35) via a replication-incompetent adenovirus (Ad.hPNPase(old-35)) in human melanoma cells and normal melanocytes results in a characteristic sensecence-like phenotype. Overexpression of hPNPase(old-35) results in increased production of ROS, leading to activation of the nuclear factor (NF)-kappaB pathway. Ad.hPNPase(old-35) infection promotes degradation of IkappaBalpha and nuclear translocation of NF-kappaB and markedly increased binding of the transcriptional activator p50/p65. Infection with (Ad.hPNPase(old-35)) enhances the production of interleukin-6 and interleukin-8, two classical NF-kappaB-responsive cytokines. hPNPase(old-35) might play a significant role in producing pathological changes associated with aging be generating proinflammatory cytokines via ROS and NF-kappaB	RNAn + a nucleoside diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
RNAn+1 + phosphate	-	Homo sapiens	RNAn + a nucleoside diphosphate	-	?
RNAn+1 + phosphate	enhanced expression of hPNPase(old-35) via a replication-incompetent adenovirus (Ad.hPNPase(old-35)) in human melanoma cells and normal melanocytes results in a characteristic sensecence-like phenotype. Overexpression of hPNPase(old-35) results in increased production of ROS, leading to activation of the nuclear factor (NF)-kappaB pathway. Ad.hPNPase(old-35) infection promotes degradation of IkappaBalpha and nuclear translocation of NF-kappaB and markedly increased binding of the transcriptional activator p50/p65. Infection with (Ad.hPNPase(old-35)) enhances the production of interleukin-6 and interleukin-8, two classical NF-kappaB-responsive cytokines. hPNPase(old-35) might play a significant role in producing pathological changes associated with aging be generating proinflammatory cytokines via ROS and NF-kappaB	Homo sapiens	RNAn + a nucleoside diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
hPNPase(old-35)	-	Homo sapiens

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Release 2023.1 (January 2023)