Literature summary for 2.7.7.8 extracted from

Chen, H.W.; Rainey, R.N.; Balatoni, C.E.; Dawson, D.W.; Troke, J.J.; Wasiak, S.; Hong, J.S.; McBride, H.M.; Koehler, C.M.; Teitell, M.A.; French, S.W.
Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis (2006), Mol. Cell. Biol., 26, 8475-8487.

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Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme depletion using RNAi does not affect mitochondrial RNA levels but impairs mitochondrial electrochemical membrane potential, decreases respiratory chain activity and correlates with altered mitochondrial morphology. This results in F0F1-ATP synthase instability, impaired ATP generation, lactate accumulation, and AMP kinase phosphorylation with reduced cell proliferation	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	localizes to the intermembrane space of mitochondria as a peripheral membrane protein in a multimeric complex	Homo sapiens	16020	-
mitochondrion	basal and interferon-beta induced enzyme is efficiently imported into mitochondria with coupled processing of the N-terminal targeting sequence. It localizes to the intermembrane space as a peripheral membrane protein in a multimeric complex	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant enzyme	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	processing of the N-terminal targeting sequence upon import into mitochondria	Homo sapiens

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Release 2023.1 (January 2023)