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Literature summary for 2.7.7.B4 extracted from

  • Leidel, S.; Pedrioli, P.G.; Bucher, T.; Brost, R.; Costanzo, M.; Schmidt, A.; Aebersold, R.; Boone, C.; Hofmann, K.; Peter, M.
    Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA (2009), Nature, 458, 228-232.
    View publication on PubMed
Search for more literature for 2.7.7.B4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Urm1p-terminal-Gly Saccharomyces cerevisiae Uba4p first adenylates and then directly transfers sulfur onto Urm1p diphosphate + Urm1p-terminal-Gly-AMP
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P38820
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Urm1p-terminal-Gly Uba4p first adenylates and then directly transfers sulfur onto Urm1p Saccharomyces cerevisiae diphosphate + Urm1p-terminal-Gly-AMP
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 ?
ATP + Urm1p-terminal-Gly Uba4p first adenylates and then directly transfers sulfur onto Urm1p. Uba4p consists of an amino N-terminal nucleotide-binding domain (NBD), followed by a MoeZ motif and a carboxy C-terminal rhodanese domain (RHD). Urm1p, adenylated by the nucleotide-binding domain (NBD) of Uba4p, is converted to a Urm1p-thiocarboxylate by Uba4p rhodanese domain (RHD). The sulfur is then passed onto U34 either directly or with the help of Ncs6p/Ncs2p Saccharomyces cerevisiae diphosphate + Urm1p-terminal-Gly-AMP
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 ?

Subunits

Subunits Comment Organism
More domain structure of Uba4p, consists of an amino N-terminal nucleotide-binding domain (NBD), followed by a MoeZ motif and a carboxy C-terminal rhodanese domain (RHD). Urm1p, adenylated by the nucleotide-binding domain (NBD) of Uba4p, is converted to a Urm1p-thiocarboxylate by Uba4p rhodanese domain (RHD). The sulfur is then passed onto U34 either directly or with the help of Ncs6p/Ncs2p Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
nucleotide-binding domain of Uba4p
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 Saccharomyces cerevisiae
Uba4
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 Saccharomyces cerevisiae