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Literature summary for 6.3.2.2 extracted from
- Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine) (1979), J. Biol. Chem., 254, 7558-7560.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| buthionine sulfoximine | inhibition is about 20times more effectively than with prothionine sulfoximine, and at least 100times more effective than methionine sulfoximine | Rattus norvegicus |  |
| methionine sulfoximine | - |
Rattus norvegicus | |
| Prothionine sulfoximine | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-Glu + L-Cys | - |
Rattus norvegicus | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? | |
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