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Gene ontology
Version 2014-12-22
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Details for GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
2.4.1.131
Gene ontology ID
GO:0004377
Definition
Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage
Synonyms
1. GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity
2. GDP-mannose-oligosaccharide-lipid mannosyltransferase activity
3. GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity
4. glycolipid 2-alpha-mannosyltransferase activity
5. guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity
6. oligosaccharide-lipid mannosyltransferase activity
References
1. EC 2.4.1.131
2. MetaCyc 2.4.1.131-RXN
3. RHEA: 29523
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