Details for N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
2.4.1.226Gene ontology ID
GO:0050510
Definition
Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP
Synonyms
1. alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase activity
2. chondroitin glucuronyltransferase II activity
3. N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity
References
1. EC 2.4.1.2262. MetaCyc 2.4.1.226-RXN3. Reactome: R-HSA-1971491 "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin"
4. Reactome: R-HSA-3595178 "Defective CHSY1 does not transfer GlcA to chondroitin"
5. Reactome: R-HSA-9632034 "CHSY1 transfers GlcA to chondroitin"
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