EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.1 | alcohol dehydrogenase |
brain |
- |
285604 |
1.1.1.10 | L-xylulose reductase |
brain |
low expression level |
656049 |
1.1.1.101 | acylglycerone-phosphate reductase |
brain |
- |
285684 |
1.1.1.102 | 3-dehydrosphinganine reductase |
brain |
- |
285699 |
1.1.1.103 | L-threonine 3-dehydrogenase |
brain |
- |
285720, 655125 |
1.1.1.105 | all-trans-retinol dehydrogenase (NAD+) |
brain |
- |
697796 |
1.1.1.105 | all-trans-retinol dehydrogenase (NAD+) |
brain |
strong mRNA expression |
692959 |
1.1.1.112 | indanol dehydrogenase |
brain |
- |
285758 |
1.1.1.14 | L-iditol 2-dehydrogenase |
brain |
- |
285879, 655289 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
brain |
- |
285912, 285930, 699476 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
brain |
- |
740247, 740503 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
brain |
significant seasonal and sexual dimorphic changes in the levels of transcript abundance in the whole brain and its regions. In whole brain, level is the highest in post-spawning phase and lowest in spawning phase in males. In females, there is a progressive increase through resting phase to pre-spawning phase, a decline in the spawning phase and increase in the post-spawning phase |
740503 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
brain |
twenty-four hours after bilateral contusion of the medial prefrontal cortex, similar levels of 3beta-hydroxysteroid dehydrogenase mRNA expression are observed in males and pseudopregnant females in the non-injured group, with a significant decrease in the 3beta-hydroxysteroid dehydrogenase mRNA expression in the contusion site within the frontal cortex in both males and pseudopregnant females. In all other regions analyzed, 3beta-hydroxysteroid dehydrogenase mRNA expression is not affected by traumatic brain injury and there is no difference between males and pseudopregnant females |
681643 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
brain |
- |
654196, 688527, 711800, 740146, 740917, 760680, 760682, 760868, 762011 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
brain |
low level of expression, low acitivity |
693886 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
brain |
weak expression |
693886 |
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
brain |
- |
763094 |
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
brain |
20alpha-HSD mRNA highly expressed |
285997 |
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
brain |
analysis of 3alpha-HSOR mRNA distribution in the mouse brain by in situ hybridization has shown that this enzyme is co-localized with 5alpha-R type 1 in neurons of the cerebral cortex, hippocampus, olfactory bulb, amygdala and thalamus. And 3alpha-HSOR immunoreactivity is largely distributed in both white and gray matters |
763094 |
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
brain |
low expression rate of AKR1C23 |
669908 |
1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) |
brain |
- |
-, 286013, 286020, 286023, 286024, 286033, 655138, 684899, 761589 |
1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) |
brain |
in all parts of the brain |
-, 286023 |
1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) |
brain |
sepiapterin reductase expression is increased in Parkinsons disease brain tissue |
685875 |
1.1.1.162 | erythrulose reductase |
brain |
- |
286091 |
1.1.1.172 | 2-oxoadipate reductase |
brain |
- |
286113 |
1.1.1.178 | 3-hydroxy-2-methylbutyryl-CoA dehydrogenase |
brain |
expressed in different regions |
673530 |
1.1.1.178 | 3-hydroxy-2-methylbutyryl-CoA dehydrogenase |
brain |
levels of SCHAD/HADII are significantly reduced in the ventral midbrain of a Parkinsons disease mouse model |
673530 |
1.1.1.184 | carbonyl reductase (NADPH) |
brain |
- |
347749, 347751, 347754, 667427, 697262 |
1.1.1.184 | carbonyl reductase (NADPH) |
brain |
strong expression of isozyme CHCR1, weaker expression of isozyme CHCR2, no expression of isozyme CHCR3 |
655213 |
1.1.1.188 | prostaglandin-F synthase |
brain |
- |
654851, 661605 |
1.1.1.188 | prostaglandin-F synthase |
brain |
enzyme is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression inneuronal cell bodies. The enzyme co-localizes with myelin basic protein in myelin sheaths but not in axons |
707934 |
1.1.1.188 | prostaglandin-F synthase |
brain |
high activity |
687797 |
1.1.1.188 | prostaglandin-F synthase |
brain |
highest activity |
687797 |
1.1.1.188 | prostaglandin-F synthase |
brain |
low expression level |
760437 |
1.1.1.189 | prostaglandin-E2 9-reductase |
brain |
- |
654851, 657211 |
1.1.1.19 | glucuronate reductase |
brain |
- |
286147 |
1.1.1.196 | 15-hydroxyprostaglandin-D dehydrogenase (NADP+) |
brain |
- |
347824, 347825, 347826 |
1.1.1.197 | 15-hydroxyprostaglandin dehydrogenase (NADP+) |
brain |
- |
347830, 347835 |
1.1.1.2 | alcohol dehydrogenase (NADP+) |
brain |
- |
-, 286164, 286166, 286168, 286172, 286174, 286175, 286176, 286177, 286178, 286181, 286182, 286183, 286184, 286186, 286190, 286214, 286215, 286217, 288554 |
1.1.1.2 | alcohol dehydrogenase (NADP+) |
brain |
midbrain, hypothalamus and pons |
286164 |
1.1.1.2 | alcohol dehydrogenase (NADP+) |
brain |
pons, medulla and midbrain |
286213 |
1.1.1.209 | 3(or 17)alpha-hydroxysteroid dehydrogenase |
brain |
- |
389547 |
1.1.1.21 | aldose reductase |
brain |
- |
286239, 286240, 286241, 286242, 286246, 738593, 761409 |
1.1.1.21 | aldose reductase |
brain |
ox |
286251, 286252 |
1.1.1.211 | long-chain-3-hydroxyacyl-CoA dehydrogenase |
brain |
- |
-, 740102, 740438 |
1.1.1.211 | long-chain-3-hydroxyacyl-CoA dehydrogenase |
brain |
adult and fetal |
670476 |
1.1.1.216 | farnesol dehydrogenase (NADP+) |
brain |
and midgut, of adult female, highest levels of mRNA |
713402 |
1.1.1.220 | 6-pyruvoyltetrahydropterin 2'-reductase |
brain |
- |
286308 |
1.1.1.220 | 6-pyruvoyltetrahydropterin 2'-reductase |
brain |
highest concentration in striatum and midbrain |
286309 |
1.1.1.225 | chlordecone reductase |
brain |
- |
286316 |
1.1.1.27 | L-lactate dehydrogenase |
brain |
- |
670394, 689715, 712102 |
1.1.1.27 | L-lactate dehydrogenase |
brain |
contains a skeletal muscle type and heart type mixed heterotetrameric enzyme, H2M2 |
740001 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
brain |
- |
286475 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
brain |
adult, juvenile, and developing |
673822 |
1.1.1.28 | D-lactate dehydrogenase |
brain |
- |
286488 |
1.1.1.284 | S-(hydroxymethyl)glutathione dehydrogenase |
brain |
- |
287888, 697214 |
1.1.1.284 | S-(hydroxymethyl)glutathione dehydrogenase |
brain |
GSNOR is the sole alcohol dehydrogenase isozyme in vertebrate brains |
726053 |
1.1.1.30 | 3-hydroxybutyrate dehydrogenase |
brain |
- |
286518, 286520, 655126, 689351 |
1.1.1.300 | NADP-retinol dehydrogenase |
brain |
- |
654687, 656098, 761195, 762061 |
1.1.1.300 | NADP-retinol dehydrogenase |
brain |
low mRNA expression |
690876 |
1.1.1.31 | 3-hydroxyisobutyrate dehydrogenase |
brain |
- |
688515 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
brain |
8% mRNA expression of Rdh5 compared to liver |
690797 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
brain |
low activity |
692700 |
1.1.1.345 | D-2-hydroxyacid dehydrogenase (NAD+) |
brain |
- |
287843 |
1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase |
brain |
- |
286269, 286589, 286591, 673340, 723558 |
1.1.1.357 | 3alpha-hydroxysteroid 3-dehydrogenase |
brain |
- |
725333, 762009, 763094, 763517 |
1.1.1.357 | 3alpha-hydroxysteroid 3-dehydrogenase |
brain |
analysis of 3alpha-HSOR mRNA distribution in the mouse brain by in situ hybridization has shown that this enzyme is co-localized with 5alpha-R type 1 in neurons of the cerebral cortex, hippocampus, olfactory bulb, amygdala and thalamus. And 3alpha-HSOR immunoreactivity is largely distributed in both white and gray matters |
763094 |
1.1.1.36 | acetoacetyl-CoA reductase |
brain |
fetal, very low expression of isozyme AKR1B15.2 |
740743 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
brain |
- |
286714, 286734 |
1.1.1.41 | isocitrate dehydrogenase (NAD+) |
brain |
- |
286757, 286758, 741458 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
brain |
- |
286792, 656588 |
1.1.1.44 | phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) |
brain |
low activity in female and male rats, constant at age 2 months to age 9 months |
655737 |
1.1.1.45 | L-gulonate 3-dehydrogenase |
brain |
- |
286909 |
1.1.1.49 | glucose-6-phosphate dehydrogenase (NADP+) |
brain |
- |
287014, 287017, 675105 |
1.1.1.49 | glucose-6-phosphate dehydrogenase (NADP+) |
brain |
negative correlation between locomotion of rats in the open field and activity of G-6-PDH in the sensorimotor cortex, especially in efferent layer V neurons and neurons of the caudate nucleus and nucleus accumbens, which attests to different capacity of the brain in Wistar rats with high and low open-field locomotion to regeneration of phosphopyridine nucleotides (NADP(+)) and production of pentoses via the pentose phosphate shunt. No correlation between enzyme activity in the hippocampus and locomotion |
697060 |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
brain |
- |
389525, 656651 |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
brain |
distribution in brain regions of cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity |
389557, 389559 |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
brain |
from male rats |
-, 741098 |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
brain |
NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity is decreased by 40-50% in lactating rats |
389559 |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
brain |
- |
699146, 761195 |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
brain |
in female hamsters |
740637 |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
brain |
isozyme 17beta-HSD8 |
675476 |
1.1.1.53 | 3alpha(or 20beta)-hydroxysteroid dehydrogenase |
brain |
- |
668684, 688455, 698084 |
1.1.1.53 | 3alpha(or 20beta)-hydroxysteroid dehydrogenase |
brain |
weak expression of subunit A, moderate expression of subunit B |
762606 |
1.1.1.55 | lactaldehyde reductase (NADPH) |
brain |
- |
389564 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
brain |
- |
656654, 688956, 740849 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
brain |
fetal, very low expression of isozyme AKR1B15.2 |
740743 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
brain |
HSD17B4 mRNA and activity are detectable in the early developing and adult brain |
711609 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
brain |
HSD17B4 mRNA is expressed more in the song regions of males compared to females throughout development. Females have significantly higher levels of HSD17B4 mRNA in auditory (caudomedial nidopallium) and visual (hyperpalliumapicale)regions than does males at day 25 |
740245 |
1.1.1.64 | testosterone 17beta-dehydrogenase (NADP+) |
brain |
low activity in both sexes |
669905 |
1.1.1.71 | alcohol dehydrogenase [NAD(P)+] |
brain |
- |
655563 |
1.1.1.77 | lactaldehyde reductase |
brain |
- |
287308 |
1.1.1.78 | methylglyoxal reductase (NADH) |
brain |
- |
207968 |
1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) |
brain |
- |
-, 287336, 287345 |
1.1.1.81 | hydroxypyruvate reductase |
brain |
- |
287380 |
1.1.1.87 | homoisocitrate dehydrogenase |
brain |
mRNA level of isoform Rdh10 declines during development, with strong and lasting expression in the meninges and choroid plexuses. Expression is also present in the striatum |
687988 |
1.1.1.88 | hydroxymethylglutaryl-CoA reductase |
brain |
results show that docosahexaenoic acid ethyl ester enhances brain HMG-CoA reductase activity in aged mice |
688564 |
1.1.1.95 | phosphoglycerate dehydrogenase |
brain |
- |
287380, 287526, 287528 |
1.1.1.95 | phosphoglycerate dehydrogenase |
brain |
enzyme expression in the subventricular neural progenitor cells, but not in differentiated neurons. The subventricular neural progenitor cells also show a decline in Phgdh expression in type B and C cells in the aged brain |
700463 |
1.1.1.95 | phosphoglycerate dehydrogenase |
brain |
Phgdh is constitutively expressed in the brain |
700437 |