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EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.244-999 - all of the mutant peptides that lost methylation capacity display no or negligible stabilization effect of NRMT1, suggesting loss of peptide binding due to residue substitution. In contrast, G1A and G1P CENP-A mutants stabilize NRMT1 by 1.5°C and 5.5°C compared with that of the NRMT1-SAH binary complex, consistent with their retained methylation capacity 756877
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.24445 - SAH-saturated NRMT1 displays a melting temperature (Tm) of 45°C, and the incubation with CENP-A (1-9) peptide further elevates the Tm by 3°C 756877
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