1.1.1.105: all-trans-retinol dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about all-trans-retinol dehydrogenase (NAD+), go to the full flat file.
Word Map on EC 1.1.1.105
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1.1.1.105
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retinoids
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dystrophy
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amaurosis
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photoreceptors
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leber
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retinaldehyde
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pigmentosa
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dehalogenase
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all-trans-retinoic
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retinol-binding
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all-trans-retinal
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raldhs
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darwin
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dehalococcoides
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11-cis-retinal
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rpgrip1
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retinyl
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dechlorination
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aldh1a2
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gucy2d
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all-trans-retinaldehyde
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cyp26b1
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cone-rod
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neurosteroidogenic
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crabp2
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albipunctatus
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organohalide
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3alpha-hydroxysteroids
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srd5a1
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hiding
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synthesis
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medicine
- 1.1.1.105
-
retinoids
- dystrophy
- amaurosis
- photoreceptors
-
leber
- retinaldehyde
- pigmentosa
-
dehalogenase
-
all-trans-retinoic
-
retinol-binding
- all-trans-retinal
- raldhs
-
darwin
- dehalococcoides
- 11-cis-retinal
-
rpgrip1
-
retinyl
-
dechlorination
- aldh1a2
-
gucy2d
- all-trans-retinaldehyde
-
cyp26b1
-
cone-rod
-
neurosteroidogenic
-
crabp2
-
albipunctatus
-
organohalide
-
3alpha-hydroxysteroids
- srd5a1
-
hiding
- synthesis
- medicine
Reaction
Synonyms
ADH, alcohol dehydrogenase, all-trans retinol dehydrogenase, all-trans-retinol dehydrogenase, dehydrogenase, retinol, DHRS9, epidermal retinol dehydrogenase 2, LOC100185899, MDR, microsomal retinol dehydrogenase, mRDH1, NAD+-dependent retinoid-active short-chain dehydrogenase/reductase, P32, PDHC, photoreceptor retinol dehydrogenase isoform C, RDH-E2, RDH-like SDR, Rdh1, RDH10, RDH10a, RDH10b, RDH10c, RDH12, RDH16, RDH2, RDH7, RDH8, RDHE2, RDHE2S, RDHL, retinal reductase, retinene reductase, retinoid dehydrogenase/reductase, retinol dehydrogenase (vitamin A1), retinol dehydrogenase 10, retinol dehydrogenase 12, retinol dehydrogenase 2, retinol dehydrogenase 4, retinol dehydrogenase epidermal 2, retinol dehydrogenase epidermal 2-similar, RL-HSD, RoDH-4, RoDH-like 3alpha-hydroxysteroid dehydrogenase, RoDH4, SDR16C5, SDR16C6, XP_2120364
ECTree
1.1.1.105 all-trans-retinol dehydrogenase (NAD+)Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.1.1.105 - all-trans-retinol dehydrogenase (NAD+)
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
13-cis-retinol + NAD+
13-cis-retinal + NADH + H+
RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol
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?
all-trans-retinal + NAD(P)H + H+
all-trans-retinol + NAD(P)+
RDH5 has only a minor in vivo all-trans RDH activity
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?
all-trans-retinol + NAD+
all-trans-retinal + NADH
RoDH-4 is capable of contributing to the oxidation of retinol to retinaldehyde for retinoic acid biosynthesis in the cellular context
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?
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
all-trans-retinal + NADH + H+
all-trans-retinol + NAD+
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r
all-trans-retinol + NAD+
all-trans-retinal + NADH + H+
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-
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?
all-trans-retinol + NAD+
all-trans-retinal + NADH + H+
exhibits a strong preference for NAD+/NADH as cofactors. Activity toward all-trans-retinal in the presence of NADH is 2fold lower than activity with all-trans-retinol and NAD+. The preference for NAD+ suggests that RDH-E2 is likely to function in the oxidative direction in vivo, further supporting its potential role in the oxidation of retinol to retinaldehyde for retinoic acid biosynthesis in human keratinocytes
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r
all-trans-retinol + NAD+
all-trans-retinal + NADH + H+
RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol
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-
?
all-trans-retinol + NAD+
all-trans-retinal + NADH + H+
RDH1 functions in a path of all-trans-retinoic acid biosynthesis starting early during embryogenesis
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?
all-trans-retinol + NAD+
all-trans-retinal + NADH + H+
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-
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r
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
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-
-
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ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
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-
-
-
?
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
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-
-
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ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
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-
-
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?
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
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ir
additional information
?
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the enzyme is expressed predominantly in the differentiating spinous layers and is under positive, feed-forward regulation by retinoic acid
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?
additional information
?
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NAD+-dependent retinoid-active SDRs have higher catalytic efficiencies for the oxidation of 3alpha-hydroxysterols than of retinols
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?
additional information
?
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RDH-E2 may be involved in the pathogenesis of psoriasis through its potential role in retinoic acid biosynthesis and stimulation of keratinocyte proliferation
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?
additional information
?
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RDH-E2 may be involved in the pathogenesis of psoriasis through its potential role in retinoic acid biosynthesis and stimulation of keratinocyte proliferation
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?
additional information
?
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chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition
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?
additional information
?
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chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition
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?
additional information
?
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RDH10 is required for proper retinoic acid signalling in the early embryo, RDH10 cooperates with retinal dehydrogenase 2 during axis development and central nervous system patterning
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?
