1.1.1.119: glucose 1-dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about glucose 1-dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.119

Reaction

D-glucose
+
NADP+
=
D-glucono-1,5-lactone
+
NADPH
+
H+

Synonyms

beta-D-glucose: NAD(P) 1-oxidoreductase, dehydrogenase, glucose (nicotinamide adenine dinucleotide phosphate), GDH, GlcDH, GlcDH 2, glucose dehydrogenase, glucose-1-dehydrogenase, halophilic glucose dehydrogenase, Hm GDH, NAD(P)+ glucose dehydrogenase, NAD(P)-dependent GDH, NADP-dependent glucose dehydrogenase, NADP-linked aldohexose dehydrogenase, nicotinamide adenine dinucleotide (phosphate)-dependent glucose-1-dehydrogenase, nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase, STK_17040

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.119 glucose 1-dehydrogenase (NADP+)

Engineering

Engineering on EC 1.1.1.119 - glucose 1-dehydrogenase (NADP+)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D172K
-
mutation in surface residue, mutant protein is slightly less halotolerant than wild-type
D172K/D216K/D344K
-
mutation in surface residue, mutant protein is slightly less halotolerant than wild-type
D216K
-
mutation in surface residue, mutant protein is slightly less halotolerant than wild-type
D344K
-
mutation in surface residue, mutant protein is slightly less halotolerant than wild-type
D38C
crystallization of a range of binary and ternary complexes of the wild-type and a D38C mutant protein
G206D
G206D/R207I
G206D/R207I/R208N
R207I
D38C
-
crystallization of a range of binary and ternary complexes of the wild-type and a D38C mutant protein
-
I189V
the mutant has decreased kcat and kcat/Km values at both 25°C and 80°C compared to the wild type enzyme
V254I
additional information