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1.1.1.132: GDP-mannose 6-dehydrogenase

This is an abbreviated version!
For detailed information about GDP-mannose 6-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.132

Reaction

GDP-D-mannose
+ 2 NAD+ +
H2O
=
GDP-D-mannuronate
 + 2 NADH + 2 H+

Synonyms

algD, GDP mannose dehydrogenase, GDP-D-mannose dehydrogenase, GDP-mannose dehydrogenase, GMD, GMD1, GMD2, guanosine diphosphate mannose dehydrogenase, guanosine diphospho-D-mannose dehydrogenase, guanosine diphosphomannose dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.132 GDP-mannose 6-dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.132 - GDP-mannose 6-dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5'-(3-hydroxypropyl)-amino-5'-deoxy-guanosine
-
only after preincubation with enzyme
5'-azido-5'-deoxy-guanosine
-
only after preincubation with enzyme
5'-azido-5'-deoxy-N2-2',3'-O-triacetylguanosine
-
only after preincubation with enzyme
5'[[[[(2'',3'',4'',6''-tetra-O-acetyl 6''-ethynyl)alpha-D-mannopyranosyl oxy]-carbonyl]amino]sulfonyl]-2',3'-isopropylidene N2-acetyl guanosine
-
GDP-analog, 0.1 mM, 60% inhibition
ambroxol
i.e. 2-amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzylamine, inhibits GMD activity, reduces the production of alginate, the expression of the important genes, and affects the structure of mucoid Pseudomonas aeruginosa biofilms, overview; reduces activity of the key enzyme GMD in alginate biosynthesis in a concentration-dependent manner
ATP
-
26% inhibition at 1 mM
C6-amido-GDP-D-mannose
mixed mechanism of inhibition
-
Ca2+
-
inhibitor of isoform GMD2 with 71.86% residual activity at 1 mM
D-maltose
-
17% inhibition at 1 mM
erythromycin
-
potent dose-dependent inhibitory effect, inhibition of biofilm formation, PT-1578
GDP-D-glucose
-
25% inhibition at 1 mM
guanosine
-
slight inhibition only after preincubation with enzyme
iodacetamide
-
40% inactivation within 30 min, complete reactivation by dithiothreitol
iodoacetamide
-
40% inactivation after 30 min preincubation
midecamycin
-
weaker inhibition, no biofilm destruction, PT-1578
N2-acetyl-2',3'-isopropylidene guanosine
-
only after preincubation with enzyme
N2-acetyl-5'-amino-5'-deoxy-2',3'-O-acetylguanosine
-
only after preincubation with enzyme
N2-acetyl-5'-amino-5'-deoxy-guanosine
-
only after preincubation with enzyme
N2-acetyl-guanosine
-
only after preincubation with enzyme
NADPH
-
weak inhibitor of reaction
p-hydroxymercuribenzoate
-
96% inactivation after 5 min preincubation; 96% inactivation within 5 min, complete reactivation by dithiothreitol
penicillic acid
-
irreversible inactivation
tetra-O-acetylmannopyranose
-
GDP-analog, 0.1 mM, 75% inhibition
Zn2+
-
potent inhibitor with 0.75% residual activity at 1 mM for both isoforms GMD1 and GMD2
additional information
-