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1.1.1.138: mannitol 2-dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about mannitol 2-dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.138

Reaction

D-mannitol
+
NADP+
=
D-fructose
+
NADPH
+
H+

Synonyms

Cla h 8, Cla h 8 allergen, D-mannitol 2-dehydrogenase, D-mannitol dehydrogenase, D-mannitol dehydrogenase, NADP-dependent, Gox1432, LRMDH, LXR1, MAD1p, mannitol 2-dehydrogenase, Mannitol 2-dehydrogenase [NADP+], mannitol dehydrogenase, mannitol dehydrogenase (NADP+), mannitol dehydrogenase (nicotinamide dinucleotide phosphate), mannitol dehydrogenase 1, MDH, More, MtDH, NADP+-dependent mannitol dehydrogenase, NADP-dependent mannitol dehydrogenase, NADP-dependent MtDH, NADP-mannitol dehydrogenase, PIG8p, PSLDR, TbMDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.138 mannitol 2-dehydrogenase (NADP+)

Reference

Reference on EC 1.1.1.138 - mannitol 2-dehydrogenase (NADP+)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Grant, C.R.; Rees, T.A.
Sorbitol metabolism by apple seedlings
Phytochemistry
20
1505-1511
1981
Laminaria digitata
-
Manually annotated by BRENDA team
Singh, M.; Scrutton, N.S.; Scrutton, M.C.
NADPH generation in Aspergillus nidulans: is the mannitol cycle involved?
J. Gen. Microbiol.
134
643-654
1988
Aspergillus nidulans
Manually annotated by BRENDA team
Hult, K.; Veide, A.; Gatenbeck, S.
The distribution of the NADPH regenerating mannitol cycle among fungal species
Arch. Microbiol.
128
253-255
1980
Alternaria alternata, Botrytis cinerea, Ceratocystis multiannulata, Cladosporium cladosporioides, Fusarium graminearum, Thermomyces lanuginosus, Neurospora crassa, Penicillium glabrum, Talaromyces islandicus
Manually annotated by BRENDA team
Stoop, J.M.H.; Mooibroek, H.
Cloning and characterization of NADP-dependent dehydrogenase cDNA from the button mushroom, Agaricus bisporus, and its expression in response to NaCl stress
Appl. Environ. Microbiol.
64
4689-4696
1998
Agaricus bisporus
Manually annotated by BRENDA team
Adachi, O.; Toyama, H.; Matsushita, K.
Crystalline NADP-dependent D-mannitol dehydrogenase from Gluconobacter suboxydans
Biosci. Biotechnol. Biochem.
63
402-407
1999
Gluconobacter oxydans, Gluconobacter oxydans IFO 12528
Manually annotated by BRENDA team
Kulkarni, R.K.
Mannitol metabolism in Lentinus edodes, the shiitake mushroom
Appl. Environ. Microbiol.
56
250-253
1990
Lentinula edodes
Manually annotated by BRENDA team
Martin, F.; Canet, D.; Marchal, J.P.
13C Nuclear magnetic resonance study of mannitol cycle and trehalose synthesis during glucose utilization by the ectomycorrhizal ascomycete Cenococcum graniforme
Plant Physiol.
77
499-502
1985
Cenococcum graniforme
Manually annotated by BRENDA team
Morton, N.; Dickerson, A.G.; Hammond, J.B.W.
Mannitol metabolism in Agaricus bisporus: Purification and properties of mannitol dehydrogenase
J. Gen. Microbiol.
131
2885-2890
1985
Agaricus bisporus
-
Manually annotated by BRENDA team
Boutelje, J.; Hult, K.; Gatenbeck, S.
Mannitol dehydrogenase from industrial waste mycelium of Penicillium chrysogenum. Purification, properties and possible use in cofactor regenerating systems in vitro
Eur. J. Appl. Microbiol. Biotechnol.
17
7-12
1983
Penicillium chrysogenum
-
Manually annotated by BRENDA team
Niehaus, W.G.; Dilts, R.P.
Purification and characterization of mannitol dehydrogenase from Aspergillus parasiticus
J. Bacteriol.
151
243-250
1982
Aspergillus parasiticus
Manually annotated by BRENDA team
Clancy, F.G.; Coffey, M.D.
Polyol dehydrogenases in the rust fungus, Melampsora lini (Ehrenb.) Lev.
J. Gen. Microbiol.
120
85-88
1980
Melampsora lini
-
Manually annotated by BRENDA team
Ruffner, H.P.; Rast, D.; Tobler, H.; Karesch, H.
Purification and properties of mannitol dehydrogenase from Agaricus bisporus sporocarps
Phytochemistry
17
865-868
1978
Agaricus bisporus
-
Manually annotated by BRENDA team
Sasajima, K.; Isono, M.
Polyol dehydrogenases in the soluble fraction of Acetobacter melanogenum
Agric. Biol. Chem.
32
161-169
1968
Gluconobacter oxydans
-
Manually annotated by BRENDA team
Strobel, G.A.; Kosuge, T.
Polyol metabolism in Diplodia viticola Desm.
Arch. Biochem. Biophys.
109
622-626
1965
Diplodia viticola Desm.
Manually annotated by BRENDA team
Edmundowicz, J.M.; Wriston, J.C.
Mannitol dehydrogenase from Agaricus campestris
J. Biol. Chem.
238
3539-3541
1963
Agaricus campestris
Manually annotated by BRENDA team
Hammond, J.B.W.
Carbohydrate metabolism in Agaricus bisporus: Oxidative pathways in mycelium and sporophore
J. Gen. Microbiol.
102
245-248
1977
Agaricus bisporus
-
Manually annotated by BRENDA team
Horer, S.; Stoop, J.; Mooibroek, H.; Baumann, U.; Sassoon, J.
The crystallographic structure of the mannitol 2-dehydrogenase NADP+ binary complex from Agaricus bisporus
J. Biol. Chem.
276
27555-27561
2001
Agaricus bisporus
Manually annotated by BRENDA team
Sassoon, J.; Horer, S.; Stoop, J.; Mooibroek, H.; Baumann, U.
Crystallization and preliminary crystallographic analysis of mannitol dehydrogenase (MtDH) from the common mushroom Agaricus bisporus
Acta Crystallogr. Sect. D
57
711-713
2001
Agaricus bisporus
Manually annotated by BRENDA team
Lee, J.K.; Koo, B.S.; Kim, S.Y.; Hyun, H.H.
Purification and characterization of a novel mannitol dehydrogenase from a newly isolated strain of Candida magnoliae
Appl. Environ. Microbiol.
69
4438-4447
2003
Starmerella magnoliae
Manually annotated by BRENDA team
Lee, J.K.; Song, J.Y.; Kim, S.Y.
Controlling substrate concentration in fed-batch Candida magnoliae culture increases mannitol production
Biotechnol. Prog.
19
768-775
2003
Starmerella magnoliae
Manually annotated by BRENDA team
Saha, B.C.
Purification and characterization of a novel mannitol dehydrogenase from Lactobacillus intermedius
Biotechnol. Prog.
20
537-542
2004
Lactobacillus intermedius
Manually annotated by BRENDA team
Klimacek, M.; Kavanagh, K.L.; Wilson, D.K.; Nidetzky, B.
Pseudomonas fluorescens mannitol 2-dehydrogenase and the family of polyol-specific long-chain dehydrogenases/reductases: sequence-based classification and analysis of structure-function relationships
Chem. Biol. Interact.
143-144
559-582
2003
Pseudomonas fluorescens
Manually annotated by BRENDA team
Trail, F.; Xu, H.
Purification and characterization of mannitol dehydrogenase and identification of the corresponding cDNA from the head blight fungus, Gibberella zeae (Fusarium graminearum)
Phytochemistry
61
791-796
2002
Fusarium graminearum
Manually annotated by BRENDA team
Sasaki, Y.; Laivenieks, M.; Zeikus, J.G.
Lactobacillus reuteri ATCC 53608 mdh gene cloning and recombinant mannitol dehydrogenase characterization
Appl. Microbiol. Biotechnol.
68
36-41
2005
Limosilactobacillus reuteri
Manually annotated by BRENDA team
Schneider, P.B.; Denk, U.; Breitenbach, M.; Richter, K.; Schmid-Grendelmeier, P.; Nobbe, S.; Himly, M.; Mari, A.; Ebner, C.; Simon-Nobbe, B.
Alternaria alternata NADP-dependent mannitol dehydrogenase is an important fungal allergen
Clin. Exp. Allergy
36
1513-1524
2006
Alternaria alternata (P0C0Y4), Alternaria alternata
Manually annotated by BRENDA team
Simon-Nobbe, B.; Denk, U.; Schneider, P.B.; Radauer, C.; Teige, M.; Crameri, R.; Hawranek, T.; Lang, R.; Richter, K.; Schmid-Grendelmeier, P.; Nobbe, S.; Hartl, A.; Breitenbach, M.
NADP-dependent mannitol dehydrogenase, a major allergen of Cladosporium herbarum
J. Biol. Chem.
281
16354-16360
2006
Cladosporium herbarum (P0C0Y5), Cladosporium herbarum
Manually annotated by BRENDA team
Voegele, R.T.; Hahn, M.; Lohaus, G.; Link, T.; Heiser, I.; Mendgen, K.
Possible roles for mannitol and mannitol dehydrogenase in the biotrophic plant pathogen Uromyces fabae
Plant Physiol.
137
190-198
2005
Uromyces viciae-fabae
Manually annotated by BRENDA team
Lee, J.; Oh, D.; Song, H.; Kim, I.
Ca2+ and Cu2+ supplementation increases mannitol production by Candida magnoliae
Biotechnol. Lett.
29
291-294
2007
Starmerella magnoliae, Starmerella magnoliae HH-01
Manually annotated by BRENDA team
Bubner, P.; Klimacek, M.; Nidetzky, B.
Structure-guided engineering of the coenzyme specificity of Pseudomonas fluorescens mannitol 2-dehydrogenase to enable efficient utilization of NAD(H) and NADP(H)
FEBS Lett.
582
233-237
2008
Pseudomonas fluorescens
Manually annotated by BRENDA team
Velez, H.; Glassbrook, N.J.; Daub, M.E.
Mannitol biosynthesis is required for plant pathogenicity by Alternaria alternata
FEMS Microbiol. Lett.
285
122-129
2008
Alternaria alternata, Alternaria alternata A5
Manually annotated by BRENDA team
Ceccaroli, P.; Saltarelli, R.; Guescini, M.; Polidori, E.; Buffalini, M.; Menotta, M.; Pierleoni, R.; Barbieri, E.; Stocchi, V.
Identification and characterization of the Tuber borchii D-mannitol dehydrogenase which defines a new subfamily within the polyol-specific medium chain dehydrogenases
Fungal Genet. Biol.
44
965-978
2007
Tuber borchii (Q1ACW3), Tuber borchii
Manually annotated by BRENDA team
Metz, B.; de Vries, R.P.; Polak, S.; Seidl, V.; Seiboth, B.
The Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism
FEBS Lett.
583
1309-1313
2009
Trichoderma reesei, Trichoderma reesei QM9414
Manually annotated by BRENDA team
Nuess, D.; Goettig, P.; Magler, I.; Denk, U.; Breitenbach, M.; Schneider, P.B.; Brandstetter, H.; Simon-Nobbe, B.
Crystal structure of the NADP-dependent mannitol dehydrogenase from Cladosporium herbarum: Implications for oligomerisation and catalysis
Biochimie
92
985-993
2010
Cladosporium herbarum (P0C0Y5), Cladosporium herbarum
Manually annotated by BRENDA team
Zahid, N.; Deppenmeier, U.
Role of mannitol dehydrogenases in osmoprotection of Gluconobacter oxydans
Appl. Microbiol. Biotechnol.
100
9967-9978
2016
Gluconobacter oxydans
Manually annotated by BRENDA team
Ortiz, M.E.; Bleckwedel, J.; Fadda, S.; Picariello, G.; Hebert, E.M.; Raya, R.R.; Mozzi, F.
Global analysis of mannitol 2-dehydrogenase in Lactobacillus reuteri CRL 1101 during mannitol production through enzymatic, genetic and proteomic approaches
PLoS ONE
12
e0169441
2017
Limosilactobacillus reuteri (A5VMM4), Limosilactobacillus reuteri CRL 1101 (A5VMM4)
Manually annotated by BRENDA team